ENGLISH

 
 
您所在的位置:首页  师资队伍  教师名单  教授

高明远


作者: 来源:放射医学与防护学院 日期:2018-05-01 2018-05-01 人气:2077 

高明远,特聘教授,博士生导师,973首席科学家,分子影像与核医学研究中心主任,中山大学附属第五医院、解放军总医院和上海健康医学院兼职教授。1996 年获得德国洪堡奖学金,2001年入选中科院“百人计划”,2002年入选德国CIM人才回归计划,2002年获国家杰出青年基金,2005年获得“百人计划”终期评估优秀奖,2006 年起享受国务院政府津贴,2011年起任973项目首席科学家,2014 年获得北京市科学技术奖一等奖(第一完成人)。现任中国研究型医院学会肿瘤影像诊断学专业委员会常委,上海市分子影像学重点实验室、中国医学科学院医学影像研究中心、天津市功能影像重点实验室、江苏省分子影像与功能影像重点实验室、分子影像湖北省重点实验室学术委员会副主任及委员。先后主持国家重点研发专项项目1项,国家重点基础研究发展计划(973计划)项目1项,863项目2项,基金委化学部杰出青年基金项目1项,基金委医学部重大项目子课题1项,基金委医学部重点项目1项,基金委重大国际合作项目2项(化学部和医学部)。截止目前,在Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed.,Adv. Mater., Nat. Comm.,Biomaterials等学术期刊上共发表学术论文160+篇,累计影响因子总和>1000+,影响因子大于10的论文65篇,累积引用14700+次。撰写中英文专著3章1部。组织境内外学术会议10+次,应邀参加学术会议做特邀及邀请报告180+次。目前,担任Current Pharmaceutical Design,Advanced Theraputics等期刊的编辑或国际顾问编委。

电子邮箱:gaomy@iccas.ac.cn

通讯地址:苏州工业园区仁爱路199号, 邮编215123
  

学习经历:

1985-1989年 吉林大学化学系高分子专业,本科生

1989-1992年 吉林大学化学系高分子专业,硕士研究生

1992-1995年 吉林大学化学系高分子专业,博士研究生,获得理学博士学位

研究方向:

1)功能无机纳米晶体的液相控制合成;

2)无机纳米晶体的光学性质及磁学性质研究;

3)无机纳米晶体在疾病诊断中的应用研究;

4)无机纳米晶体在生物分析中的应用研究;

5)有机/无机纳米晶体功能杂化材料的结构设计与性质研究。

  

代表性论文:

        1.Coordinatively Unsaturated Fe3+ Based Activable Probes for Enhanced MRI and Therapy of Tumors
Peisen Zhang, Yi Hou*, Jianfeng Zeng, Yingying Li, Zihua Wang, Ran Zhu, Tiancong Ma, and Mingyuan Gao*
Angew. Chem. Int. Ed., 2019, DOI: 10.1002/anie.201904880.

        2. Multispectral Upconversion-Optoacoustic Imaging of Redox Correlation for Dynamic Profiling of Inflammation Progression
Xiangzhao Ai‡, Zhimin Wang‡, Yong Wang, Ruochong Zhang, Jun Lin, Yuanjing Zheng, Mingyuan Gao*, Bengang Xing*
Nat. Comm., 2019, 10, 1087.

        3. Quantitatively Visualizing Tumor-related Protease Activity In Vivo Using A Ratiometric Photoacoustic Probe
Ling Yin, Hao Sun, Hao Zhang, Lei He, Ling Qiu, Jianguo Lin, Huawei Xia, Yuqi Zhang, Shunjun Ji, Haibin Shi*, Mingyuan Gao*
J. Am. Chem. Soc., 2019, 141(7), 3265-3273.

        4. Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in vivo
Tiancong Ma‡, Yi Hou‡, Jianfeng Zeng‡, Chunyan Liu, Peisen Zhang, Lihong Jing, Dihua Shangguan, and Mingyuan Gao*
J. Am. Chem. Soc., 2018, 140(1), 211-218.

        5. Tumor Microenvironment-Triggered Aggregation of Anti-Phagocytosis 99mTc-Labelled Fe3O4 Nanoprobes for Enhanced Tumor Imaging in Vivo
Zhenyu Gao‡, Yi Hou‡, Jianfeng Zeng, Lei Chen, Chunyan Liu, Wensheng Yang*, and Mingyuan Gao*
Adv. Mater., 2017, 29(24), 1701095.

        6. Molecular Imaging of Vulnerable Atherosclerotic Plaques In Vivo with Osteopontin-Specific Upconversion Nanoprobes
Ruirui Qiao‡, Hongyu Qiao‡, Yan Zhang, Yabin Wang, Chongwei Chi, Jie Tian, Lifang Zhang, Feng Cao*, and Mingyuan Gao*
ACS Nano, 2017, 11(2), 1816-1825.

        7. Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo
Xiaju Cheng, Rui Sun, Ling Yin, Zhifang Chai, Haibin Shi*, and Mingyuan Gao*
Adv. Mater., 2017, 29(6), 1604894.

        8. Aqueous Based Semiconductor Nanocrystals
Lihong Jing‡, Stephen V. Kershaw‡, Yilin Li, Xiaodan Huang, Yingying Li, Andrey L. Rogach*, and Mingyuan Gao*
Chem. Rev., 2016, 116(18), 10623-10730.

        9. Graphene Oxide-based Sensor for Ultrasensitive Visual Detection of Fluoride
Tapas K. Manda‡, Yi Hou‡, Zhenyu Gao, Haoran Ning, Wensheng Yang, and Mingyuan Gao*
Adv. Sci., 2016, 3(12), 1600217.

        10. Ultrasmall Biocompatible WO3-x Nanodots for Multi-modality Imaging and Combined Therapy of Cancers
Ling Wen, Ling Chen, Shimin Zheng, Jianfeng Zeng, Guangxin Duan, Yong Wang, Guanglin Wang, Zhifang Chai, Zhen Li*, Mingyuan Gao*
Adv. Mater., 2016, 28(25), 5072-5079.

        11. Protease-Activated Ratiometric Fluorescent Probe for pH Mapping of Malignant Tumors
Yi Hou, Jin Zhou, Zhenyu Gao, Xiaoyu Sun, Chunyan Liu, Dihua Shangguan, Wensheng Yang, and Mingyuan Gao*
ACS Nano, 2015, 9(3), 3199-3205.

        12. Ultrasensitive in Vivo Detection of Primary Gastric Tumor and Lymphatic Metastasis Using Upconversion Nanoparticles
Ruirui Qiao‡, Changhao Liu‡, Muhan Liu, Hao Hu, Chunyan Liu, Yi Hou, Kaichun Wu*, Yenan Lin, Jimin Liang, Mingyuan Gao*
ACS Nano, 2015, 9(2), 2120-2129.

        13. Insight into Strain Effects on Band Alignment Shifts, Carrier Localization and Recombination Kinetics in CdTe/CdS Core/Shell Quantum Dots
Lihong Jing‡, Stephen V. Kershaw‡, Tobias Kipp‡, Sergii Kalytchuk, Ke Ding, Jianfeng Zeng, Mingxia Jiao, Xiaoyu Sun, Alf Mews, Andrey L. Rogach, and Mingyuan Gao*
J. Am. Chem. Soc., 2015, 137(5), 2073-2084.

        14.Magnetically Engineered Semiconductor Quantum Dots as Multimodal Imaging Probes
Lihong Jing, Ke Ding, Stephen V. Kershaw, Ivan M. Kempson, Andrey L. Rogach*, and Mingyuan Gao*
Adv. Mater., 2014, 26(37), 6367-6386.

        15. Are Rare-Earth Nanoparticles Suitable for In Vivo Applications?
Chunyan Liu, Yi Hou, and Mingyuan Gao* 
Adv. Mater., 2014, 26(40), 6922-6932.

        16. Anchoring Group Effects of Surface Ligand on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents
Jianfeng Zeng, Lihong Jing, Yi Hou, Mingxia Jiao, Ruirui Qiao, Qiaojuan Jia, Chunyan Liu, Fang Fang, Hao Lei, and Mingyuan Gao* 
Adv. Mater., 2014, 26(17), 2694-2698.

        17.Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo
Chunyan Liu, Zhenyu Gao, Jianfeng Zeng, Yi Hou*, Fang Fang, Yilin Li, Ruirui Qiao, Lin Shen, Hao Lei, Wensheng Yang, and Mingyuan Gao*
ACS Nano, 2013, 7(8), 7227-7240.

        18. NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts In Vivo
Yi Hou, Ruirui Qiao, Fang Fang, Xuxia Wang, Chengyan Dong, Kan Liu, Chunyan Liu, Zhaofei Liu, Hao Lei*, Fan Wang, and Mingyuan Gao*
ACS Nano, 2013, 7(1), 330-338.

        19. Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood-Brain Barrier
Ruirui Qiao, Qiaojuan Jia, Sabine Hüwel, Rui Xia, Ting Liu, Fabao Gao*, Hans-Joachim Galla*, and Mingyuan Gao*
ACS Nano, 2012, 6(4), 3304-3310.

        20. Gelification: An Effective Measure for Achieving Differently Sized Biocompatible Fe3O4 Nanocrystals through a Single Preparation Recipe
Qiaojuan Jia, Jianfeng Zeng, Ruirui Qiao, Lihong Jing, Liang Peng, Fenglong Gu*, and Mingyuan Gao* 
J. Am. Chem. Soc., 2011, 133(48), 19512-19523.