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杨凯


作者: 来源:放射医学与防护学院 日期:2017-12-06 2017-12-06 人气:6011 

杨凯,博士, 副教授 , 硕士生导师

电话:0512-65882263  

电子邮箱:kyang@suda.edu.cnyangjie3411@126.com

通讯地址:苏州工业园区仁爱路199401319, 邮编215123

个人简历:

2006年获得安徽工程大学生化工程系工学学士学位,2009年获得苏州大学基础医学与生物科学学院理学硕士学位,2013年获得苏州大学功能纳米与软物质研究院理学博士学位,2012年至2013年在美国国立卫生研究院进行博士联合培养。20141月加入苏州大学医学部放射医学与防护学院,被聘为副教授,硕士生导师。

研究方向:

近年来一直在纳米生物医学和放射医学这一交叉领域从事研究, 2010以来共发表了SCI论文80余篇,相当一部分成果发表于Chem. Soc. Rev., Adv. Drug Deliver. Rev., Nature Protocols, Adv. Mater., Adv. Funct. Mater., Nano Lett., ACS Nano, Small, Biomateirals等国际权威刊物上。论文总他人引用次数已超过7500次,SCI H-index39

本课题组的研究领域是纳米医学与放射医学,这是一门跨越材料、化学、生物医学和放射医学的交叉学科。我们的目标是开发新型功能纳米材料,研究其在生命体系中的行为,并利用纳米材料独特的物理与化学性质以发展新型多模态生物影像技术、靶向药物输送技术、以及肿瘤物理联合治疗,从而探索癌症的诊断与治疗的新思路与新方法。主要研究方向如下:

- 新型功能纳米材料在多模态生物成像与肿瘤联合治疗中的应用

- 基于生物材料的肿瘤光学治疗与联合治疗研究

- 基于功能纳米材料的肿瘤放射治疗

获得的奖励:

2016年获得江苏省科学技术奖一等奖(第二完成人)

2015年获得苏州大学“东吴学者”

2015年获得苏州市高等院校、科研院所紧缺高层次人才

2015年江苏省优秀博士论文

2014年获得教育部自然科学二等奖(第三完成人)

代表性论著:

1. Xuan Yi, Lei Chen, Jie Chen, Debabrata Maiti, Zhifang Chai, Zhuang Liu, Kai Yang*, Biomimetic Copper Sulfide for Chemo-radiotherapy: Enhanced Uptake and Reduced Efflux of Nanoparticles for Tumor Cells under Ionizing Radiation. Advanced. Functional. Materials, 2017, 10.1002/adfm.201705161z

2. Longlong Tian, Qian Chen, Xuan Yi, Jiawen Chen, Chao Liang, Yu Chao, Kai Yang*, Zhuang Liu*, Albumin-Templated Manganese Dioxide Nanoparticles for Enhanced Radioisotope Therapy. Small 2017, 13, 1700640.

3. Longlong Tian, Qian Chen, Xuan Yi, Guanglin Wang, Jie Chen, Ping Ning, Kai Yang*, Zhuang Liu*, Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer. Theranostics, 2017; 7(3): 614-623.

4. He Zhao, Yu Chao, Jingjing Liu, Jie Huang, Jian Pan, Wanliang Guo, Jizhi Wu, Mao Sheng, Kai Yang*, Jian Wang*, Zhuang Liu*, Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy. Theranostics, 2016; 6(11): 1833-1843.

5. Xujiang Yu, Ang Li, Chengzhi Zhao, Kai Yang*, Xiaoyuan Chen, Wanwan Li*, Ultrasmall Semimetal Nanoparticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic Thermoradiotherapy. ACS Nano, 2017, 11 (4): 3990–4001.

6. Xujiang Yu, Kai Yang*, Xiaoyuan Chen, Wanwan Li *, Black hollow silicon oxide nanoparticles as highly efficient photothermal agents in the second near-infrared window for in vivo cancer therapy. Biomaterials, 2017, 143, 120-129.

7. Jie Chen, Meifang Li, Xuan Yi, Qi Zhao, Lei Chen, Chen Yang*, Jinchang Wu*, Kai Yang*, Synergistic Effect of Thermo-Radiotherapy Using Au@FeS Core–Shell Nanoparticles as Multifunctional Therapeutic Nanoagents. Particle & Particle System Characterization. 2017, 1600330.

8. Xiaojun Yu, Xing Tang, Jingkang He*, Xuan Yi, Guiying Xu, Longlong Tian, Rui Zhou, Chen Zhang, and Kai Yang*, Polydopamine Nanoparticle as a Multifunctional Nanocarrier for Combined Radiophotodynamic Therapy of Cancer. Particle & Particle System Characterization. 2017, 1600296.

9. Kai Yang*, Liangzhu Feng, Zhuang Liu*, Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy. Advanced Drug Delivery Reviews, 2016, 105: 228–241.

10. Meifang Li, Qi Zhao, Xuan Yi, Xiaoyan Zhong, Guosheng Song, Zhifang Chai, Zhuang Liu*, Kai Yang*, Au@MnS@ZnS Core/Shell/Shell Nanoparticles for Magnetic Resonance Imaging and Enhanced Cancer Radiation Therapy. ACS Applied Materials &Interfaces 2016, 8, 9557?9564.

11. Qi Zhao, Xuan Yi, Meifang Li, Xiaoyan Zhong, Quanliang Shi*, Kai Yang*, High near-infrared absorbing Cu5FeS4 nanoparticles for dual-modal imaging and photothermal therapy. Nanoscale, 2016, 8, 13368–13376.

12. Xuan Yi, Lei Chen, Xiaoyan Zhong, Roulin Gao, Yitao Qian, Fan Wu, Guosheng Song, Zhifang Chai, Zhuang Liu, Kai Yang*, Core–shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation. Nano Research 2016, 9(11): 3267–3278.

13. Yu Chao, Guanglin Wang, Chao Liang, Xuan Yi, Xiaoyan Zhong, Jingjing Liu, Min Gao, Kai Yang*, Liang Cheng*, Zhuang Liu *, Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-Sensitized, Near-Infrared Enhanced Radioisotope Therapy. small 2016, 12(29):3967–3975.

14. Lei Chen, Xiaoyan Zhong, Xuan Yi, Min Huang, Ping Ning, Teng Liu, Cuicui Ge, Zhifang Chai, Zhuang Liu*, Kai Yang*, Radionuclide 131I labeled reduced graphene oxide for nuclear imaging guided combined radio- and photothermal therapy of cancer. Biomaterials, 2015, 66, 21-28.

15. Xuan Yi, Kai Yang*, Chao Liang, Xiaoyan Zhong, Ping Ning, Guosheng Song, Dongliang Wang, Cuicui Ge, Chunying Chen, Zhifang Chai, Zhuang Liu *, Imaging-Guided Combined Photothermal and Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine-131-Doped Copper Sulfide Nanoparticles. Advanced. Functional. Materials. 2015, 25, 4689–4699.

16. Xiaoyan Zhong, Kai Yang*, Zhiliang Dong, Xuan Yi, Yong Wang, Cuicui Ge, Yuliang Zhao, Zhuang Liu*, Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer. Advanced. Functional. Materials. 2015, 25, 7327–7336.

17. Kai Yang*, Guangbao Yang, Lei Chen, Liang Cheng, Lu Wang, Cuicui Ge, Zhuang Liu*, FeS nanoplates as a multifunctional nano-theranostic for magnetic resonance imaging guided photothermal therapy. Biomaterials, 2015, 38, 1-9.

18. Guosheng Song, Chao Liang , Hua Gong , Meifang Li , Xianchuang Zheng , Liang Cheng, Kai Yang* , Xiqun Jiang , Zhuang Liu *, Core-Shell MnSe@Bi 2Se3 Fabricated via a Cation Exchange Method as Novel Nanotheranostics for Multimodal Imaging and Synergistic Thermoradiotherapy, Advanced Materials, 2015, 27, 6110–6117

19. Kai Yang*, Liangzhu Feng, Zhuang Liu, The advancing uses of nanographene in drug delivery. Expert Opinion on Drug Delivery, 2014, 12(5): 601-612.

20. Kai Yang* Guangbao Yang, Lei Chen, Liang Cheng, Lu WangCuicui Ge,  Zhuang Liu " FeS nanoplates as a multifunctional nano-theranostic for magnetic resonance imaging guided photothermal therapy ". Biomaterials, 2015, 38, 1-9.  

21. Kai Yang*, Liangzhu Feng, Zhuang Liu "The advancing uses of graphene in drug delivery". Expert Opinion on Drug Deliver, 2014, 12 (5) : 1-12 (Invited Review, in press)

22. Kai Yang?, Lei Zhu?, Liming Nie, Xiaolian Sun, Liang Cheng, Gang Niu, Xiaoyuan Chen* and Zhuang Liu* “Visualization of protease activity in vivo using an activatable photoacoustic imaging probe based on CuS nanoparticles” Theranostics,20144(2)134-141

23. Kai Yang, Liangzhu Feng, Hao Hong, Weibo Cai and Zhuang Liu*. “Preparation of functionalized nano-graphene bioconjugates for biomedical applications” Nature Protocols.2013, 8(12) 2392-2403

24. Kai Yang, Hua Gong, Xiaoze Shi, Jianmei Wan, Youjiu Zhang, Zhuang Liu. “In vivo biodistribution and toxicology of functionalized nano-graphene oxide in mice after oral and intraperitoneal administration”. Biomaterials. 2013, 34, 2787-2795.

25. Kai Yang, Liangzhu Feng, Xiaoze Shi, Zhuang Liu* “Nano-graphene in biomedicine: theranostic applications” Chem. Soc Rev. 2013, 42: 530-547. (Invited Review)

26. Kai Yang, Yingjie Li, Xiaofang Tan, Rui Peng*, Zhuang Liu*. “Behaviors and toxicity of graphene oxide and its functionalized derivatives in biological systems. Small, 2013, 9, 1492–1503. (Invited Review)

27. Kai Yang?, Huan Xu?, Liang Cheng, Zhuang Liu* “In vitro and in vivo near-infrared photothermal therapy of cancer using Polypyrrole organic nanoparticles” Adv. Mater. 2012, 24, 5586–5592. (? equal contribution authors)

28. Kai Yang, Jianmei Wan, Shuai Zhang, Bo Tian, Youjiu Zhang, Zhuang Liu * “The influence of surface chemistry and size of nanoscale graphene oxide on photothermal therapy of cancer using ultra-low laser power” Biomaterials, 2012 33: 2206-2214.

29. Kai Yang, Lilei Hu, Xingxin Ma, Shuoqi Ye, Changhui Li, Yonggang Li, Zhuang Liu* “Multi-modal imaging guided photothermal therapy using functionalized graphene nano-sheets anchored with magnetic nanoparticles” Adv. Mater. 2012, 24: 1868-1872. (Frontispiece)

30. Kai Yang, Zhuang Liu* “In vivo biodistribution, pharmacokinetics, and toxicology of carbon nanotubes” Cure. Drug Metab, 2012, 13: 1057-1067.

31. Kai Yang, Jianmei Wan, Shuai Zhang, Youjiu Zhang, Shuit-Tong Lee, Zhuang Liu* “In vivo Pharmacokinetics, Long-Term Biodistribution, and Toxicology of PEGylated Graphene in Mice” ACS Nano, 2011, 5(1): 516-522.

32. Kai Yang, Shuai Zhang, Guoxin Zhang, Xiaoming Sun, Shuit-Tong Lee and Zhuang Liu,* “Graphene in Mice-Ultra-high in vivo Tumor Uptake and Highly Efficient Photothermal Therapy” Nano Lett. 2010, 10: 3318–3323. (Highlighted by Nature)