孟烜宇 副教授

日期:2016-7-1 17:07:49 人气:123 

孟烜宇,副教授

孟烜宇2011年博士毕业于吉林大学理论化学研究所。2009年公派留学至美国弗吉尼亚联邦大学医学院进行博士研究,毕业后继续在该院从事博士后和研究员工作。于20145月加入苏州大学医学部放射医学与防护学院。孟烜宇主要从事生物大分子的计算机模拟研究,研究方向涉及离子通道等跨膜蛋白的作用机制、蛋白质相互作用、药物小分子设计等。特别对钾离子通道有深入研究。目前已发表英文学术书籍1章,SCI论文20篇。其中钾通道论文以Feature Article发表在《Biophysical Journal》上,多篇文章发表在《Natural Chemical Biology,Proc. Natl. Acad. Sci.,Science Advances》,《Scientific Reports》《Journal of Biological Chemistry》等杂志上。主持国家自然科学基金青年基金项目一项(2016-2018)。

代表论文

1.X.Y. Meng, H.X. Zhang, D.E. Logothetis, M. Cui, “The molecular mechanism by which PIP2 opens the intracellular G-loop gate of a Kir3.1 channel”, Biophy. J., 102(2012), 2049-2059.

2.X.Y. Meng, S.Liu,M. Cui, R. Zhou, D. E. Logothetis, “The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel”, Sci. Rep., being published.

3.X.Y. Meng, B. Li, S. Liu, H. Kang, L. Zhao, R. Zhou, “EGCG in Green Tea Induces Aggregation of HMGB1 Protein through Large Conformational Changes with Polarized Charge Redistribution”, Sci. Rep., being published

4.M. Zhang, X.Y. Meng, M. Cui, J.M. Pascal, D.E. Logothetis, J.F. Zhang, “Selective phosphorylation mudulates the PIP2 sensitivity of the CaM-SK channel complex”. Nat. Chem. Biol. 10(2014), 753-759.

5.M. Zhang, X.Y. Meng, J.F. Zhang, M. Cui, D. E. Logothetis, “Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides”, Science Advances, 1(2015), e1500008.

6.A.A. Rodriguez-Menchaca, S.K. Adney, Q.Y. Tang, X.Y. Meng, A. Rosenhouse-Dantsker, M. Cui, D.E. Logothetis, “PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker”, Proc. Natl. Acad. Sci., 109(2012), 14299–14300.

7.D.E. Logothetis, V. I. Petrou, R. Mahajan, X.Y. Meng, S. K. Adney, L. Baki, M. Cui, “Phosphoinositide Control of Transmembrane Protein Activity: A New Frontier Led by Ion Channels”, Ann Rev Physiol.,77(2015), 81-104.

8.B. Liu, M. Ha, X.Y. Meng, T. Kaur, M. Khaleduzzaman, Z. Zhang, P.H. Jiang, X. Li, M. Cui, “Molecular Mechanism of Species-Dependent Sweet Taste for Dipeptide Artificial Sweetners”, J. Neurosci. 31(2011),11070-11076.

9.Y. Xu, Y. Wang, X.Y. Meng*, M. Zhang, M. Jiang, M. Cui, G.N. Tseng, “Building KCNQ1/KCNE1 Channel Models and Probing their Interactions by Molecular-Dynamics Simulations”, Biophy. J., 105 (2013), 2461-2473.co-first author

10.X.Y. Meng, Q. C. Zheng, H. X. Zhang, “A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies”, BBA-Proteins Proteom., 1794 (2009) 1066–1072.

11.X.Y. Meng, H. X. Zhang, M. Mezei, R. Osman, M. Cui, “Molecular Docking: A powerful approach for structure-based drug discovery”, Curr. Comput-Aid. Drug, 7(2011), 146-157.

12.X.Y. Meng, H.X. Zhang, M. Mezei, M. Cui, “Protein-Protein Docking using a Brownian Dynamics Simulations Approach”, J. Biomed. Biotechnol., 2012(2012), doi:10.1155/2012/121034.

13.X.Y. Meng, M. Mezei,M. Cui, Computational Approaches for Modeling GPCR Dimerization”, Curr. Pharm. Biotech., 15(2014): 996–1006.

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