Strategy for Enhanced Antibacterial Activity against Staphylococus aureus by Assembly of Alamethicin with Thermo-Sensitive Polymeric Carrier

日期:2016-4-21 13:28:27 人气:43 

Ping Dong, Yuan Zhou, Weiwei He,Daoben Hua, Strategy for Enhanced Antibacterial Activity against Staphylococus aureus by Assembly of Alamethicin with Thermo-Sensitive Polymeric Carrier, Chem. Commun., 2015, DOI: 10.1039/C5CC07054F

Abstract:

We demonstrate here a strategy for enhanced antibacterial activity against microbial strains by assembly of antimicrobial peptides with temperature-responsive polymeric carrier. The assembly complex was less toxic to human cells and more stable to enzymatic cleavage. This work may provide a promising drug delivery system for antimicrobial peptides.

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