苏州大学放射生物学研究中心

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07-03/2025

曹建平教授团队与吴德沛教授团队合作揭示棉子糖代谢细菌调控辐射相关造血恢复的新机制

近日，苏州大学放射医学与辐射防护国家重点实验室曹建平教授团队和国家血液系统疾病临床研究中心/苏州大学附属第一医院血液科吴德沛教授合作团队在辐射相关造血恢复的调控机制方面取得新进展，相关成果以“Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway”为题发表在《Gut Microbes》杂志上。论文链接：https://doi.org/10.1080/19490976.2025.248

畅磊教授与张增利教授团队联合揭示细胞力学通过自噬调控铁死亡敏感性的分子机制

畅磊教授与张增利教授课题组联合在 Autophagy 期刊发表了题为 “Autophagy induced by mechanical stress sensitizes cancer cells to ferroptosis by NCOA4-FTH1 axis”的研究论文（DOI ：10.1080/15548627.2025.2469129）。该研究揭示了细胞力学通过NCOA4介导的 FTH1自噬调控铁死亡敏感性的分子机制，强调了细胞力学微环境在铁死亡调控中的核心作用，并为临床放射治疗提供了新的研究视角。已有研究表明，细胞密度可影响铁死亡敏感性。例如，依赖细

02-18/2025

李明副教授与附二院田野教授团队合作在放射性肠损伤救治领域取得新进展

苏州大学放射医学与防护学院李明副教授和附二院田野教授团队合作在《Gut Microbes》（中科院1区Top，影响因子12.200）杂志上在线发表了题为“Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics” (DOI: 10.1080/19490976.2024.2347722)的研究论文。辐射诱导的肠道病变（rad

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2024
1.    Feng, Y. et al. Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury. Experimental and Molecular Medicine 56, 1107-1122, doi:10.1038/s12276-024-01208-z (2024).
2.    Geng, F. H. et al. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cellular & molecular immunology 21, 856-872, doi:10.1038/s41423-024-01185-3 (2024).
3.    Geng, F. H. et al. A Frog Skin-Derived Peptide Targeting SCD1 Exerts Radioprotective Effects Against Skin Injury by Inhibiting STING-Mediated Inflammation. Adv Sci 11, doi:10.1002/advs.202306253 (2024).
4.    Ji, M. T. et al. Mechano-YAP/TAZ-regulated smooth muscle cells are an important source of Wnt signalling for gut regeneration. Clin Transl Med 14, doi:ARTN e7000510.1002/ctm2.70005 (2024).
5.    Shu, Y. Y. et al. Ku70 Binding to YAP Alters PARP1 Ubiquitination to Regulate Genome Stability and Tumorigenesis. Cancer Res. 84, 2836-2855, doi:10.1158/0008-5472.Can-23-4034 (2024).
6.    Tang, Y. T. et al. USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling. Int. J. Radiat. Oncol. Biol. Phys. 119, 1261-1274, doi:10.1016/j.ijrobp.2024.01.220 (2024).
7.    Wang, P. et al. Vitamin D receptor attenuates carbon tetrachloride-induced liver fibrosis via downregulation of YAP. J Hazard Mater 478, doi:ARTN 13548010.1016/j.jhazmat.2024.135480 (2024).
8.    Yin, X. H. et al. Rational Design of Dual-Functionalized Gd@C82 Nanoparticles to Relieve Neuronal Cytotoxicity in Alzheimer's Disease via Inhibition of Aβ Aggregation. ACS nano 18, 15416-15431, doi:10.1021/acsnano.3c08823 (2024).
9.    Xie, L. W. et al. Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics. Gut Microbes 16, doi:Artn 234772210.1080/19490976.2024.2347722 (2024).
10. Xie, L. W. et al. Probiotic Consortia Protect the Intestine Against Radiation Injury by Improving Intestinal Epithelial Homeostasis. Int. J. Radiat. Oncol. Biol. Phys. 120, 189-204, doi:10.1016/j.ijrobp.2024.03.003 (2024).