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Ping-Kun ZHOU


 日期:2015-6-18 9:32:47 人气:129 

Name: Ping-Kun ZHOU

Date of birth: 10 September, 1963

Nationality: Chinese

Address: Department of Radiation Toxicology and Oncology

Beijing Institute of Radiation Medicine

27 Taiping Road, Beijing 100850

P. R. China

Phone: 86-10-68213912

Fax: 86-10-68183899

E-mail: zhoupk@me.com ; zhoupk@bmi.ac.cn

                        Assistant: birm4th@163.com

PRESENT POSITION

l Director, Professor,  Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing, China

l Chief Professor,  School of Radiation Medicine and Protection (SRMP), RAD-X of Medical College of Soochow University, SuZhou, Jiangsu Province, China

l Director, Beijing Key Laboratory for Radiobiology, Beijing, China

EDUCATION AND QUALIFICATION

Bachelor of Medicine: Xiangya Medical College, Central South University, Changsha, China (1980.09-1985.07)

MSc: Beijing Institute of Radiation Medicine, Beijing, China.

Major in Biochemistry (1987.09-1990.07)

M.D. / Ph.D.: Beijing Institute of Radiation Medicine, AMMS, Beijing, China.

Major in Toxicology & Radiation Biology (2001.09-2004.07)

PROFESSIONAL EXPERIENCES

1985.08 Research trainee, Beijing Institute of Radiation Medicine (BIRM), AMMS, China

1992.08 Research assistant, Department of Biochemistry, BIRM, AMMS, China

1993.12 Associate professor, Department of Biochemistry, BIRM, China

1994.03 – 1995.03 Visiting School, Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, The United Kingdom

1996.05 Deputy head, Department of Biochemistry and Molecular Biology, BIRMChina

1998.03 – 2000.03 Visiting Researcher,  UMR218, Institut Curie Recherche, 26 rue d’ulm, 75231Paris Cedex05; CEA, Laboratoire Mixte INRA-CEA de Radiobiologie et Etude du Genome, Jouy en Josas Cedex, France

Present Director, Professor, Department of Radiation Toxicology and Oncology,

Director, Committee of Science and Technology, BIRM-AMMS, China

MEMBERSHIP in PROFESSIONAL ORGANISATIONS

President, Chinese Society of Toxicology

Associate Editor, Toxicology Research (RSC, UK),

Associate Editor, Food & Chemical Toxicology (USA)

Councilor,  ASIATOX

Councilor, Chinese Society of Radiation Medicine and Protection.

RESEARCH PROJECTS ONGOING

973 Program of the MOST, China (#2015CB910601). 8,680,000 RMB.

PI, DNA damage sinaling and response mechanism.

863 Program of the MOST, China (#2012AA063501). 8,300,000 RMB, Chief Scientist.

973 Program of the MOST, China (#2007CB914603). 14,500,000 RMB

Chief Scientist, DNA damage response protein complex and the related functional mechanisms in DNA repair.

Outstanding Youth Scientist Foundation of NSFC, China (#30825011). 2, 000,000 RMB

PI, Genomic DNA damage and cytogentic effect induced by space radiation and the protective measure study.

NSFC, China (No: 30772592).  320, 000 RMB

PI, Mitotic catastrophe induced by a novel anticancer drug BVAN08 and the related mechanism.

IAEA coordination project (No:12510/R4). 32,000 EURO

PI, The studies of HIV proteins influencing cellular radiao- sensitivity and the acting mechanisms.

PUBLICATIONS LIST

1. Zou LH, Shang ZF, Tan W, Liu XD,  Xu QZ, Song M, Wang Y, Guan H, Zhang SM, Yu L, Zhong CG, Zhou PK. TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1. Oncotarget, 2015, 6(9): 7011-7022.

2. Zhang SM, Shang F, Zhou PK. Autophagy as the effector and player in DNA damage response of cells to genotoxicants. Toxicology Research, 2015, 4: 613-622

3. Li M, Cui F, Cheng Y, Han L, Wang J, Sun D, Liu YL, Zhou PK, Min R. Gelsolin: Role of a Functional Protein in Mitigating Radiation Injury. Cell Biochem Biophys, 2015, 71(1): 389-396

4. Zhang SM, Zhang H, Yang TY, Ying TY, Yang PX, Liu XD, Tang SJ, Zhou PK. Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination. Int J Biol Sci, 201410(10):1138-1149.

5. Liu X, Qiu F, Liu Z, Lan Y, Wang K, Zhou PK, Wang Y, Hua ZC. Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway. Apoptosis, 2014, 19(10):1532-1544.

6. Li MJ, Cui FM, Cheng Y, Sun D, Zhou PK, Min R. Changes in the adhesion and migration ability of peripheral blood cells: potential biomarkers indicating exposure dose. Health Phys, 2014, 107(3):242-247.

7. Chen Y, Zhou PK, Zhang XQ, Wang ZD, Wang Y, Darroudi F. Cytogenetic studies for a group of people living in Japan 1 year after the Fukushima nuclear accident. Radiat Prot Dosimetry, 2014,159(1-4):20-25.

8. Wang ZD, Hu HL, Hu M, Zhang XQ, Wang Q, Qiao YL, Liu HX, Shen LP, Zhou PK, Chen Y. Ratio of γH2AX level in lymphocytes to that in granulocytes detected using flow cytometry as a potential biodosimeter for radiation exposure. Radiation Environ Biophysics, 2014, 53(2):283-90.

9. Huang B, Shang ZF, Li B, Wang Y, Liu XD, Zhang SM, Guan H, Rang WQ, Hu JA, Zhou PK. DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis. Journal of Cellular Biochemistry, 2014, 115(6):1077-1088

10. Gu Y, Wang J, Li S, Kamiya K, Chen X, Zhou P. Determination of the biochemical properties of full-length human PIF1 ATPase. Prion, 2013, 7(4): 341-347.  

11. Li B, Shang ZF, Yin JJ, Xu ZH, Liu XD, Wang Y, Zhang SM, Guan H, Zhou PK. PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis. Int J Biol Sci, 2013; 9(4): 425-434.  

12. Tu WZ, Li B, Huang B, Wang Y, Liu XD, Guan H, Zhang SM, Tang Y, Rang WQ, Zhou PK.γH2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway. FEBS Letters, 2013, 587: 3437-3443.

13. Sui L, Wang Y, Wang X, Kong FQ, Liu JC, Zhou PK. Clustered DNA damage induced by protons radiation in plasmid DNA. Chinese Science Bulletin, 2013, 58(26): 3217-3223.

14. Cui FM, Li JX, Chen Q, Du HB, Zhang SY, Nie JH, Cao JP, Zhou PK, Hei TK, Tong J. Radon-Induced Alterations in Micro-RNA Expression Profiles in Transformed BEAS2B Cells. J Toxicol Environ Health A. 2013, 76(2):107-119.  1.

15. Wang Y, Wang Z, Joshi BH, Puri RK, Stultz B, Yuan Q, Bai Y, Zhou P, Yuan Z, Hursh DA, Bi X. The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity. Oncogene, 2013, 32(33):3857-3866.

16. Shang ZF, Yu L, Li B, Tu WZ, Wang Y, Liu XD, Guan H, Huang B, Rang WQ, Zhou PK. 4E-BP1 participates in maintaining the spindle integrity and genomic stability via interacting with PLK1. Cell Cycle, 2012,11(18): 3463 – 3471

17. Zhang SM, Song M, Yang TY, Fan R, Liu XD, Zhou PK. HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and Cyclin B1 ternary complex. Cell Cycle, 2012, 11(6): 1217-1234.

18. Chen Y, Yan XK, Du J, Wang ZD, Zhang XQ, Zeng FG, Zhou PK. Biological dose estimation for accidental supra-high dose gamma-ray exposure. Radiation Measurements. 2011, 46:837-841.

19. Qin X, Zhang SM, Li B, Liu XD, He XP, Shang ZF, Xu QZ, Zhao ZQ, Ye QN, Zhou PK. p53-dependent upregulation of PIG3 transcription by g-ray irradiation and its interaction with KAP 1 in responding to DNA damage. Chinese Science Bulletin, 2011, 56: 3162-3171.

20. Nie J, Liu L, Zhao XH, Xie P, Zhou PK, Xing GC, Liu XJ, He FC, Han WD, Zhang LQ. DNA damage stree induces the dissociation of Smurf1/2 from MDM2 in a slow manner. Chinese Science Bulletin, 2011, 56(3): 3155-3161

21. Zhou PK. DNA Damage, Signaling and Repair: Protecting genomic integrity and reducing the risk of human disease. Chinese Science Bulletin, 2011, 56: 3119-3121

22. Zhang B, Huang B, Guan H, Zhang SM, Xu QZ, He XP, Liu XD, Wang Y, Shang ZF, Zhou PK. Proteomic profiling revealed the functional networks associated with mitotic catastrophe of HepG2 hepatoma cells induced by 6-bromine-5-hydroxy-4-methoxybenzaldehyde. Toxicology and Applied Pharmacology, 2011, 252:307-317.

23. An J, Yang TY, Huang YC, Liu F, Sun JF, Wang Y, Xu QZ, Wu DC, Zhou PK. Strand-specific PCR of UV radiation-damaged genomic DNA revealed an essential role of DNA-PKcs in the transcription-coupled repair. BMC Biochemistry, 2011, 12:2. doi:10.1186/1471-2091-12-2.

24. Du L, Zhou LJ, Pan XJ, Wang YX, Xu QZ, Yang ZH, Wang Y, Liu XD, Zhu MX, Zhou PK. Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo. Radiation Oncology, 2010, 5:70. doi:10.1186/1748-717X-5-70.

25. Yan XK, Zhang N, Chen Y, Du J, Cao ZS, Zhou PK. Splitting of cell clumps in cytokinesis-blocked micronucleus images: application to improve the recognition ability of binucleated lymphocytes. Cytometry A, 2010, 77(8):783-789.

26. Shang ZF, Huang B, Xu QZ, Zhang SM, Fan R, Liu XD, Wang Y, Zhou PK. Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated Chk2 phosphorylation in response to DNA damage. Cancer Research, 2010, 70(9): 3657-3666.

27. An J, Huang YC, Xu XZ, Zhou LJ, Shang ZF, Huang B, Wang Y, Liu XD, Wu DC, Zhou PK. DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Molecular Biology, 2010, 11(1):18.

28. Zhang SM, Sun Y, Fan R, Xu QZ, Liu XD, Zhang X, Wang Y, Zhou PK. HIV-1 Tat regulates cyclin B1 by promoting both expression and degradation. FASEB J, 2010, 24(2):495-503.

29. Hu YC, Yang ZH, Zhong KJ, Niu LJ, Pan XJ, Wu DC, Sun XJ, Zhou PK, Zhu MX, Huo YY. Alteration of transcriptional profile in human bronchial epithelial cells induced by cigarette smoke condensate. Toxicol Lett, 2009, 190(1):23-31.

30. Zhou PK, Sun Y, An J. Interaction between viral proteins and hosts and its disturbance in the cellular responses to ionizing radiation (Invited review for 5th Annuversary of IJRB). Int J Radiat Biol, 2009, 85(7): 587-597.

31. Ding KK, Shang ZF, Hao C, Xu QZ, Shen JJ, Yang CJ, Xie YH, Qiao C, Wang Y, Xu LL, Zhou PK. Induced expression of the IER5 genes by γ-ray irradiation and its involvement in cell cycle checkpoint control and survival. Radiat Environ Biophys, 2009, 48(2):205-213.

32. Ding K, Yang C, Shen J, Xu L, Li Y, Zhou P, Zeng Y. Gamma-ray Up-regulated Holocarboxylase Synthetase Gene. Cell Mol Neurobiol, 2009, 29(3):383-389.

33. Chen Y, Jin CZ, Zhang XQ, Ge SL, Zhang ZY, Xu H, Liu XL, Wu DC, Zhou PK. Seventeen-year follow-up study on chromosomal aberrations in five victims accidentally exposed to several Gy of 60Co g-rays. Radiat Environ Biophys, 2009, 48(1):57-65.

34. An J, Yang DY, Xu QZ, Zhang SM, Huo YY, Shang ZF, Wang Y, Wu DC, Zhou PK. DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein. Molecular Cancer, 2008, 7:e32(1-12).

35. Huo YY, Li G, Duan RF, Gou Q, Fu CL, Hu YC, Song BQ, Yang ZH, Wu DC, Zhou PK. PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts. Free Radical Biology Medicine. 2008, 44:1578-1591.

36. Zheng H, Chen ZW, Wang L, Wang SY, Yan YQ, Wu K, Xu QZ, Zhang SM, Zhou PK. Radioprotection of 4-hydroxy-3,5-dimethoxybenzaldehyde (VND3207) in culture cells is associated with minimizing DNA damage and activating Akt. Eur J Pharmaceut Sci. 200833:52-59.

37. Yan YQ, Zhang B, Wang L, Xie YH, Peng T, Bai B and Zhou PK. Induction of apoptosis and autophagic cell death by the vanillin derivative 6-bromine-5-hydroxy-4- methoxybenzaldehyde is accompanied by the cleavage of DNA-PKcs and rapid destruction of c-Myc oncoprotein in HepG2 cells. Cancer Letters, 2007, 252: 280-289.

38. Long XH, Zhao ZQ, He XP, Wang HP, Xu QZ, An Jing, Bai B, Sui JL, and Zhou PK. Dose-dependent expression changes of early response genes to ionizing radiation in human lymphoblastoid cells. Int J Mol Med, 2007, 19(4): 607-616.

39. Huo YY., Hu YC, He XR, Wang Y, Song BQ, Zhou PK, Zhu MX, Li G and Wu DC. Activation of extracellular signal-regulated kinase by TGF-β1 via TβRII and Smad7 dependent mechanisms in human bronchial epithelial BEP2D cells. Cell Biology Toxicology, 2007, 23(2): 113-128.

40. Yan YQ, Xu QZ, Wang L, Sui JL, Bai B and Zhou PK. Vanillin derivative 6-bromine-5-hydroxy-4- methoxybenzaldehyde-elicited apoptosis and G2/M arrest of Jurkat cells proceeds concurrently with DNA-PKcs cleavage and Akt inactivation. Int J Oncology, 2006, 29:1167-1172.

41. Ding XM, Duan YY, Peng CS, Feng HS, Zhou PK, Meng JG, Xue ZQ, XU QZ. Dexamethasone treatment attenuates early seawater instillation-induced acute lung injury rabbits. Pharmacological Research, 2006, 53:372-379.

42. Sun Y, Huang YC, Xu QZ, Wang HP, Bai B, Sui JL and Zhou PK. HIV-1 Tat depresses DNA-PKcs expression and DNA repair, and sensitizes cells to ionizing radiation. Int J Radiat Oncol Biol Biophy, 2006, 65(3): 842-850.

43. Wang HP, Long XH, Sun ZZ, Rigaud O, Xu QZ, Huang YC, Sui JL, Bai B and Zhou PK. Identification of differentially transcribed genes in human lymphoblastoid cells irradiated with 0.5 Gy of g-ray and the involvement of low dose radiation inducible CHD6 gene in cell proliferation and radiosensitivity. Int J Radiat Biol, 2006, 82(3): 181-190.

44. Liu F, Yu ZJ, Sui JL, Bai B and Zhou PK. siRNA-mediated silencing of CSB potentiates radiation-induced apoptosis and antiproliferative effect in HeLa cells. Chinese Med J, 2006, 119(9):731-739.

45. An J, Xu QZ, Sui JL, Bai B and Zhou PK. Silencing of DNA-PKcs alters the transcriptional profile of certain signal transduction genes related to proliferation and differentiation in HeLa cells. Int J Mol Med, 2005, 16(3): 455-462.

46. An J, Xu QZ, Sui JL, Bai B and Zhou PK. Down-regulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cells. Int J Cancer, 2005, 117, 531-537.

47. Sui JL, An J, Sun JF, Chen Y, Wu DC and Zhou PK. Spindle checkpoint and apoptotic response in α particles-transformed human bronchial epithelial cells. Radiat Environment Biophysics, 2004, 43(4): 257-263.

48. Ding XM, Xu QZ, Liu FG, Zhou PK, Gu Y, Zeng J, An J, Dai WD, Li XS. Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation. Cancer Letters, 2004, 216: 43–54.

49. Sun JF, Sui JL, Zhou PK, Geng Y, Hu YC, Cao ZS, Ge SL, Lou TZ and Wu DC. Decreased efficiency of γ-ray-induced DNA double-strand break rejoining in malignant transformants of human bronchial epithelial cells generated by alpha-particle exposure. Int J Radiat Biol, 2002, 78(9): 773-780.

50. Zhou PK, Rigaud O. Down-regulation of the human CDC16 gene following ionizing radiation: a possible role in the radioadaptive response. Radiation Research, 2001, 155(1): 43-49.

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