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史海斌


 日期:2016-10-10 10:31:51 人气:140 

史海斌,青年千人、特聘教授、博士生导师

电话:0512-65882973

传真:0512-65884380

电子邮箱:hbshi@suda.edu.cn

通讯地址:苏州工业园区仁爱路199, 邮编215123

课题组网页:http://fyxy.suda.edu.cn/Imaging/

个人简介:

史海斌现为苏州大学医学部放射医学与防护学院教授。2006年于苏州大学获得有机化学硕士学位,2006-2011年在新加坡国立大学化学系获得博士学位,2011-2012年于新加坡国立大学化学与生物分子工程系从事研究助理工作。2012-2014年在美国斯坦福大学(Stanford University)医学院分子影像中心从事博士后研究。长期致力于智能有机分子探针的构建及在肿瘤药物靶标分析和重大疾病(包括肿瘤)的早期诊断及治疗方面的应用研究。近几年已经在国际著名学术期刊如J. Am. Chem. Soc.Angew. Chem. Intl. Ed.Adv. MatersChem. Comm.J. Mater. Chem.Nat. Protocols等杂志上发表论文共23篇(其中以第一作者身份发表13篇),引用700次,参与撰写英文书籍1部,拥有国际专利3项。2016年入选国家中组部第十二批“青年千人计划”。目前受邀担任ProteomicsProteomics Clinical Applications等国际期刊的编委。目前主持国家重点研发计划数字诊疗装备研发重点专项(青年项目)、国家基金委面上项目、江苏省高校自然基金重大项目和苏州市科技计划项目各1项。

研究方向:

? 肿瘤相关蛋白酶特异性智能分子探针的开发与研究

? 发展多模态或多功能分子影像探针及其在癌症诊断与治疗中的应用研究

? 放射性药物分子的合成与高通量筛选

科研项目:

1. 中组部第十二批青年千人计划,2016年,200万,主持。

2. 国家重点研发计划数字诊疗装备研发重点专项(青年项目),2016YFC0101200,肿瘤诊疗与原位疗效评价一体化探针构建及应用研究,2016/07-2019/06100万,在研,主持

3. 国家自然科学基金面上项目,21572153,生物条形码标记纳米探针体内检测肿瘤酶的

研究,2016/01-2019/12, 77.4万,在研,主持。

4. 江苏省高校自然基金重大项目,15KJA310004,多功能纳米探针在多模态肿瘤成像和治

疗中的应用研究,2015/07-2018/06, 15万,在研,主持。

5. 苏州市科技计划项目,SYG201520,智能型多模态纳米探针在肿瘤诊疗中的应用研究,2015/07-2019/068万,在研,主持。

代表性论著:

1. Cheng, X. J.; Sun, Rui.; Yin, L.; Chai, Z. F.; Shi, H*, Gao, M. Y*. Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumours In Vivo. Adv. Mater. 2016, In press.

2. Shi, H.; Cheng, Y, F.; Lee, K. H.; Luo, R. F.; Banaei, N.; Rao, J*. H. Engineering Stereochemistry of Cephalosporin for Specific Detection of Metallo-β-Lactamase-Expressing Pathogenic Bacteria. Angew. Chem. Intl. Ed.  2014, 53, 8113–8116.

3. Shi, H.; Ryan, K. T. K.; Tang, B. Z*.; Liu, B*. Real-Time Monitoring of Cell Apoptosis and Drug Screening Using Fluorescent Light-Up Probe with Aggregation-Induced Emission Characteristics. J. Am. Chem. Soc. 2012, 134, 17972–17981.

4. Shi, H.; Liu, J.; Geng, J.; Tang, B. Z*.; Liu, B*. Specific Detection of Integrin αVβ3 by Light-Up Bioprobe with Aggregation-induced Emission Characteristics. J. Am. Chem. Soc. 2012, 134, 9569–9572.

5. Shi, H.; Zhang, C.; Chen, G.Y.J.; Yao, S. Q*. Cell-Based Proteome Profiling of Potential Dasatinib? Targets Using Affinity-Based Probes (AfBPs). J. Am. Chem. Soc. 2012, 134, 30013014.

6. Shi, H.; Cheng, X.; Sze, S.K.; Yao, S. Q*. Proteome Profiling Reveals Potential Cellular Targets of Staurosporine Using a Clickable Cell-Permeable Probe. Chem Comm, 2011, 47, 11306–11308.

7. Shi, H.; Liu, K.; Xu, A.; Yao, S. Q*. Small Molecule Microarray (SMM)-facilitated Screening of Affinity-based Probes (AfBPs) for g-secretase. Chem. Comm. 2009, 5030–5032.

8. Shi, H.; Uttamchandani, M.; Yao, S. Q*. Applying Small Molecule Microarrays and Resulting Affinity Probe Cocktails for Proteome Profiling of Mammalian Cell Lysates. Chem. -Asian. J. 2011, 6, 28032815.

9. Shi, H.; Zhao, N.; Ding, D.; Liang, J.; Tang, B. Z*.; Liu, B*. In Vivo Imaging of Cell Apoptosis Using Fluorescent Light-Up Probe with Aggregation-Induced Emission Characteristics. Org. Biomol. Chem. 2013, 11(42), 72897296.

10. Shi, H.; Wang, G.; Liang, J.; Liu, B*. Fluorescence turn-on detection of live cell apoptosis using a hyperbranched conjugated polyelectrolyte. Med. Chem. Commun. 2013, 4, 554558.

11. Shi, H.; Liu, K.; Leong, W. Y. W.; Yao, S. Q*. Expedient Solid-Phase Synthesis of Both Symmetric and Asymmetric Diol Libraries Targeting Aspartic Proteases. Bioorg. Med. Chem. Lett. 2009, 19, 3945–3948.

12. Shi, H.; Uttamchandani, M.; Yao, S.Q. A Method for Small Molecule Microarray-based Screening for the Rapid Discovery of Affinity-based Probes. Methods Mol. Bio., 2010, 669, 57–68.

13. Liang, J.;Shi, H.; Kwok, R. T. K.; Gao, M.; Yuan, Y. Y.; Tang, B. Z*.; Liu, B*. Distinct Optical and Kinetic Responses from E/Z Isomers of Caspase Probes with Aggregation-Induced Emission Characteristics. J. Mater. Chem. B. 2014, 2, 43634370. ( Co-first author).

14. Shi, H.; Ji, S*,; Bian, B. Studies on Transition Metal Ions Recognition Properties of 1-(2-benzothiazole)-3-(2-thiophene)-2-pyrazoline Derivatives. Dyes and Pigments, 2007, 73(3), 394–396.

15. Shi, H.; Ji, S*.; Zhang, Y. Synthesis and Crystal Structures of Pyrazoline Derivants. Chinese Journal of Structural Chemistry. 2005, 24(5), 586590.

16. Ji, S*.; Shi, H. Synthesis and Fluorescent Property of Some Novel Benzothiazoyl Pyrazoline Derivatives containing Aromatic Heterocycle. Dyes and Pigments, 2006, 70, 246–250.

17. Liu, K.; Shi, H.; Xiao, H.; Chong, A.G.L.; Bi, X.; Chang, Y. T., Tan, K.; Yada, R. Y.; Yao, S. Q*. Functional Profiling, Identification and Inhibition of Plasmepsins in Intraerythrocytic Malaria Parasites. Angew. Chem. Intl. Ed., 2009, 48, 8293–8297.

18. Loh, Y.; Shi, H.; Hu, M.; Yao, S. Q*. Click Synthesis of Small Molecule-Peptide Conjugates for Organelle-Specific Delivery and Inhibition of Lysomosal Cysteine Proteases, Chem. Commun. 2010, 46, 8407–8409.

19. Kalesh, K.A.; Shi, H.; Ge, J.; Yao, S. Q*. The Use of Click Chemistry in the Emerging Field of Catalomics. Org. Biol. Chem., 2010, 8, 1749–1762.

20. Sun, H.; Lu, C.H.S.; Shi, H.; Gao, L.; Yao, S. Q*. Peptide Microarrays for High-throughput Studies of Ser/Thr Phosphatases. Nat. Protocols, 2008, 3, 1485–1493.

21. Bian, B.; Ji, S*.; Shi, H. Synthesis and Fluorescent Property of Some Novel Bischromophore Compounds containing Pyrazoline and Naphthalimide Groups. Dyes and Pigments. 2008, 76, 348–352.

22. Ding D.; Liang, J.; Shi, H.; Kwok, R. T. K.; Gao, M.; Yuan, Y. Y.; Tang, B. Z*.; Liu, B*. Light-Up Bioprobe with Aggregation-Induced Emission Characteristics for Real-Time Apoptosis Imaging in Target Cancer Cells, J. Mater. Chem. B, 2014, 2, 231238.

23. Geng, J. L.; Liu, J.; Liang, J.; Shi, H.; Liu, B*. A General Approach to Prepare Conjugated Polymer Dot Embedded Silica Nanoparticles with a SiO2@CP@SiO2 Structure for Targeted HER2-Positive Cellular Imaging. Nanoscale. 2013, 5, 85938601.

24. Liang, J.; Kwok, R. T. K.; Shi, H.; Tang, B. Z*.; Liu, B*. Fluorescent Light-up Probe with Aggregation-Induced Emission Characteristics for Alkaline Phosphatase Sensing and Activity Study, ACS Appl. Mater. Interf. 2013, 5, 87848788.

专利:

1. 一种紫外光介导的纳米颗粒自组装聚集体、其制备方法和应用,中国发明专利,2016年,申请号:201610723117.1

2. Heterocycle-functionalized luminogens exhibiting aggregation-induced emission. US Patent Provisional. 2014, US2014/0348753.

3. Biocompatible Nanoparticles with Aggregation-Induced Emission Characteristics as Far-Red/Near-infrared Fluorescent Bioprobes for In Vitro and In Vivo Imaging Applications. PCT Patent 2014, WO2013/029340.

4. Probes for Detecting Carbapenem-resistant Bacteria. US Patent Provisional. 2015, File No. US61/928,524.

荣誉奖励:

1. 20163月获国家中组部第十二批青年千人计划

2. 20169月获江苏省第十三批“六大人才高峰”高层次人才选拔培养资助(已公示)

3. 20161月获苏州市高等院校、科研院所紧缺高层次人才

课程教学:

新生研讨课:《分子探针---揭示生命奥秘的钥匙》

留学生课程:《Organic Chemistry

招生信息:

常年招收具有化学、材料学、生物学、医学和医学影像等背景的硕士研究生、博士生、博士后及科研助理。欢迎化学专业及医学类本科生来实验室开展毕业设计。


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