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许玉杰


 日期:2017-9-21 10:22:47 人气:398 

许玉杰,教授、硕士生导师

电话:0512-65880061     传真:0512-65884380

电子邮箱:dbnm@suda.edu.cn  xuyuj@hotmail.com

通讯地址:苏州工业园区仁爱路199号, 邮编215123

个人简历:

许玉杰,苏州大学医学部放射医学与防护学院副院长,分子影像与核医学研究中心教授。

1985.6 原苏州医学院放射医学系放射医学专业毕业,获医学学士并留校任教;1990.6 原苏州医学院放射医学系放射医学专业研究生毕业,获医学硕士学位;2008.6 苏州大学放射医学与公共卫生学院博士研究生毕业,获医学博士学位。1998–1999到日本国家原子能研究所(高崎)生物技术研究室,任外国研究员。2001年8月被聘为苏州大学副教授,担任基础核医学教研室主任;2016.8 被聘为苏州大学教授。主要从事基础核医学教学和核素示踪研究工作。曾经担任的学术和社会兼职包括:中国核工业教育学会副理事长(2014),中国核学会同位素分会理事(第四、六届),中国生物物理学会辐射与环境专业委员会委员(2015),中国毒理学会放射毒理专业委员会委员(2012),全国核能标准化技术委员会放射性同位素分技术委员会(SAC/TC58/SC4)委员(2004),《中华放射医学与防护杂志》第七、八、九届编辑委员会委员,《中国辐射卫生杂志》第四、五届编辑委员会委员,江苏省医学会第七、八届核医学分会委员(2012、2015),江苏省核学会核医学专业委员会第七届委员(2010)。

   许玉杰教授于2014年荣获教育部高等学校科学研究优秀成果奖(技术发明二等奖,排名3/6,证书号:2014-167 ),中国核能行业协会科学技术奖(技术发明二等奖,排名3/6,证书号2014HNJ13R-03)和苏州市科学技术进步奖(二等奖,排名2/5,证书号2-18-2)。其主编的教材《实验核医学》获得苏州大学精品教材(2005)和优秀教学成果二等奖(2004)。

研究方向:

   研究与开发核医学使用的放射性核素靶向诊断与治疗药物,特别是核酸识别、抗体识别和配体-受体识别的靶向放射性药物。

   研究和发现可以应用于肿瘤核医学显像与治疗的新靶点和新的细胞调控机制。

   新型辐射防护材料、促排药物的研究和开发。

科研项目:

1.        国家自然基金面上项目:多巴胺纳米粒子透过血脑屏障的实验研究。项目批准号:302704112003.01-2005.1219万元,主持。

2.        国家自然科学基金面上项目:细胞核靶向的富勒醇硬脂质纳米粒的辐射防护作用。项目批准号:309708732010.01-2012.1230万元,主持。

3.        国家自然科学基金面上项目,新型放射免疫治疗药物X-HOPO-mAb的研究。项目批准号:3114751242015.1-2018.1298万元,主持。

4.        江苏省新世纪高等教育教学改革工程研究课题(C类),加强核医学特色专业建设的研究。2003-20051万元,主持。

代表性论著:

1.       Zhan,Yan-Hua ; Sun, Ru ; Zhu, Wei-Jin ; Xu, Yu-Jie* ; Ge, Jian-Feng*. An oxazine-based near-infrared fluorescent probefor selective in cellular imaging of exogenous nitrite. Sensors &Actuators: B. Chemical, 2017,240, 1283-1290. (Correspondence author

2.       Wang, Xiu-Li; Li , Xiao-Jun; Sun, Ru*; Xu ,Yu-Jie  andJian-Feng Ge*. A comparative study of lysosome-targetable pHprobes based on phenoxazinium attached with aliphatic and aromatic amines. Analyst,2016, 141, 2962

3.       ZhanYan-Hua LiXiao-Jun Sun Ru *Xu,Yu-Jie Ge Jian-Feng *. Distinguishing normal cells from cancer cellsvia lysosome-targetable pH biomarkers with benzo[a]phenoxazine skeleton. AnalyticaChimica Acta2016 933175-181

4.       Chen, Li; Chen,Bizheng; Liu,Xiaodong;Xu,Yujie; Zhang,Lifen*; Cheng, Zhenping * and Zhu,Xiulin.Real-time monitoring of a controlled drug delivery system in vivo: constructionof a near infrared fluorescence monomer conjugated with pH-responsive polymericmicelles. J. Mater. Chem. B, 2016, 4, 3377

5.       Xiao,Jin-Wei; Zhu,Wei-Jin; Sun,Ru *; Xu,Yu-Jieand Ge,Jian-Feng *. Evaluation of electron or charge transfer processes betweenchromenylium-based fluorophores and protonated–deprotonated aniline. RSC Adv.,2016, 2016,6, 98985-98993

6.       Liu,Xiaodong ; Chen, Bizheng; Li, Xiaojun; Zhang, Lifen ; Xu, Yujie *;   Liu Zhuang*; Cheng,Zhenping *and  Xiulin Zhu. Self-assembly of BODIPY based pH-sensitivenear-infrared polymeric micelles for drug controlled delivery and fluorescenceimaging applications. Nanoscale. 20157(39):16399-416. (IF 7.394,1 Correspondence author,

7.       He, Dan-DanLiu, WuSunRu *FanChen XuYu-Jieand GeJian-Feng *.N-Pyridineium-2-yl Darrow Red Analogue: Unique Near-Infrared Lysosome-Biomarkerfor the Detection of Cancer Cells. Anal. Chem., 2015, 87 (3): 1499–1502 (IF5.636,

8.       Liu, Wu;Fan,Chen; Sun, Ru*; Xu,Yu-Jie; Ge,Jian-Feng*. Near-infrared emission of dibenzoxanthenium and its application in thedesign of nitric oxide probes.  Org Biomol Chem. 201513(15):4532-8

9.       Miao, Jia-Tao; Fan,Chen; Shi, Xiao-Yu; Sun, Ru*, XuYu-Jie  and Ge, Jian-Feng *. Colorimetric and ratiometric pH responses by theprotonation of phenolate within hemicyanine. Analyst.2014, 139, 6290-6297IF3.9

10.    Sun Ru?Liu,Xiao-Dong Zhan Xuna; Lu,Jian-Mei; Xu,Yu-Jie ;Ge,Jian-Feng? .Arosamine-based red-emitting fluorescent sensor for detecting intracellular pHin live cells. Sensors and Actuators B: Chemical. 2014 (201) 426–432IF3.84

11.   LiuXiao-Dong ; FanChen;  SunRu;  Xu, Yu-Jie *; Ge ,Jian-Feng *..Nile-redand Nile-blue-based near-infrared fluorescent probes for in-cellulo imaging ofhydrogen sulfide. Anal Bioanal Chem 2014, 406:7059–7070 (PAPER INFOREFRONT, IF 3.7, Correspondenceauthor)

12.   Miao, Jia-TaoFan, Chen Sun, Ru*,XuYu-Jie  and Ge, Jian-Feng *.Optical propertiesof hemicyanines with terminal amino groups and their applications in nearinfrared fluorescent imaging of nucleoli. J. Mater. Chem. B, 2014, 2,7065-7072

13.   Liu ,Xiao-Dong; Sun,Ru;, Ge,Jian-Feng *;  Xu, Yu-Jie *; Xu,Ying and Lu, Jian-Mei*. A squaraine-based red emission off onchemosensor for biothiols and its application in living cells imaging. Org.Biomol. Chem. 2013; 11:4258-4264.(IF 3.568, Correspondence author

14.    SunRu; Liu, Wu; Xu,u-Jie; Lu, Jian-Mei* ; Ge, Jian-Feng * and MasatakaIhara . Cyanobenzo[a]phenoxazine-basednear infrared lysosome-tracker for in cellulo imaging. Chem. Commun. 2013, 49,10709-10711.IF6.378  

15.   Liu, Xiao-Dong; Xu,Ying ;Sun, Ru*;  Xu,Yu-Jie ; Lu ,Jian-Mei* Ge, Jian-Feng *.A coumarin–indole-based near-infrared ratiometric pH probe for intracellularfluorescence imaging . Analyst. 2013 ,38(21):6542-50

16.   Qi,Xiuxiu;Li,Najun*;Gu, Hongwei; Xu,Yujie; Xu,Ying; Jiao,Yang; Xu, Qing feng; Li, Hua and Lu,Jianmei*.Amphiphilicoligomer-based micelles as cisplatin nanocarriers for cancer therapy. Nanoscale2013, 5, 8925-8929 IF6.233

17.     Liu, Xiao-Dong SunRu ?Xu,  Ying  XuYu-JieGe Jian-Feng*LuJian-Mei*. A  benzoxazine–hemicyanine   based  probe   for   the  colorimetric   and   ratiometric detection  of  biothiols. Chemical. Sensors  and   Actuators  B  178(2013) 525–  531. IF3.535

18.   Liu,Wu; Sun, Ru ; Ge ,Jian-Feng*; Xu, Yu-Jie; Xu, Ying ; Lu,Jian-Mei *; Itoh,Isaum, and Ihara, Masataka *.Reversible Near-Infrared pH Probes Based onBenzo[a]phenoxazine. Anal. Chem., 2013, 85 (15):7419–7425IF5.695

19.   Mei,XiaoChen, DongyunLi, NajunXu, QingfengGeJianfeng *Li,Hua Yang,BaixiaXuYujie * and LuJianmei *.Facile preparation of coating fluorescent hollow mesoporous silicananoparticles with pH-sensitive amphiphilic diblock copolymer for controlleddrug release and cell imaging. Soft Matter. 2012, 8, 5309IF4.75Correspondence author

20.   Qian-Qian Zhang,Bai-Xia Yang,Ru Sun, Jian-Feng Ge  *,Yu-Jie Xu *,Na-Jun Li,Jian-MeiLu * .A near-infrared phenoxazinium-based fluorescentprobe for Zinc ions and imaging in living cells. Sensors and Actuators B 171– 172 (2012) 1001– 1006IF3.8, Correspondence author

21.    Cai,XY;Kong,XM;Fang,Q;Ning,P;Xu,YJ;Zhang,B;Xue,SR. Anautoradiographic study on the pathogenesis of levodopa-induced dyskinesia:regulation of dopamine transporter by levodopa in a rat model of Parkinson'sdisease. Neurodegener Dis. 2012;9(1):11-7

22.    Yang,Xue-Bo;Yang,Bai-Xia; Ge,Jian-Feng*;Xu,Yu-Jie; Xu, Qing-Feng*;Liang,Jie and Lu,Jian-Mei*.Benzo[a]phenoxazinium-Based Red-Emitting Chemosensor for Zinc Ions inBiological Media. Organic Letters,2011,13(10):2710-2713 IF5.5, 2区)

23.    Xu,Yu-Jie;Li,Qing-Nuan;Zhu,Ran;Zhu,Ben-Xing;Zhang,Yong-Ping;Zhang,Xiao-dong;Fan, Wo; Hong, Cheng-Jiao; Li,wen-xin. Radiotoxicity induced by Augerelectron emitters in human osteosarcoma cell using comet assay. Nuclear Scienceand Techniques.2003,14(3):171-

24.    M.Taguchi,K.Hayano, Yujie Xu, M. Moriyama, Y. Kobayashi , H. Hiratsuka, S-H Ohno:Yields of tyrosines in the radiolysis of aqueous phenylalanine solutions byenergetic heavy ions. Radiation Physics and Chemistry,2001,60:263-268

25.    许莹、樊辰、许玉杰*、杨百霞、周捷波、李海龙。细胞核靶向富勒醇固体脂质纳米粒对小鼠亚致死剂量辐射损伤的预防作用. 辐射防护2015.35(5):284-288.(通讯作者)

26.    张刘珍,许玉杰,刘敏,翁婉雯,丁文秀,杨占山.高脱乙酰度低分子量聚糖的制备与鉴定。辐射研究与辐射工艺学报,200927(3)177-181. (通讯作者)

27.    张刘珍,许玉杰,王畅,翁婉雯, 丁文秀,杨占山.CTS-EDTA 的合成与鉴定及其体外螯合Sr2 +的研究[J].中国辐射卫生,2009,18(1):36(通讯作者)

28.    WENG Wan-weng, XU Yu-jie,WAN Jian-mei,WANG Zhong-zhan,DING Wen-xiu,LIUMin, HONG Cheng-jiao .Molecular mechanism of radiosensitization effect ofpaclitaxel .Chinese Journal of Cancer,2009,28(8):844-850(通讯作者)

29.    王宗站,许玉杰*,汪梅花,刘敏,李智慧,翁婉雯,张刘珍:紫杉醇脂质纳米粒子对KBSKOV3细胞的抑制作用。肿瘤 20082811):921-924(通讯作者)

30.    汪梅花,许玉杰*,王宗站,刘敏,胡明江,范我:放射性核素125I标记紫杉醇方法学研究。同位素,2008212):82-87(通讯作者)

31.    许玉杰主编,《实验核医学》,苏州大学出版社,2004

32. 张起虹,涂彧,许玉杰,《医用电离辐射防护与安全》,江苏人民出版社,2007


专利

1.  富勒醇脂质纳米粒及其制备和应用。ZL201110439349.1,授权日期:2014.6 发明人:许玉杰、刘敏、杨百霞、孙俊杰

2.  新型防辐射材料及制成的手套,申请号:201510969259.1,申请日期:2015.12.22,发明人:许玉杰、王敬东、陈碧正

荣誉奖励:

1.   教育部高等学校科学研究优秀成果奖--技术发明二等奖,2014,排名3/6,证书号:2014-167

2.   中国核能行业协会科学技术奖--技术发明二等奖, 2014,排名3/6,证书号2014HNJ13R-03

3.   苏州市科学技术进步奖 ---二等奖,2014,排名2/5,证书号2-18-2

课程教学及招生信息

课程教学

1.    《实验核医学》主讲教师,放射医学专业核医学课程组专业课程。

2.    《核科学概论》主讲教师,公共通识选修课程。

3.    《医用核技术》主讲教师,放射医学专业选修课。

4.    《辐射防护培训》主讲教师,卫生部、环保部指定的放射性工作人员的培训

招生信息:

招收放射医学硕士研究生,包括理学、医学类研究生。学习背景:临床医学、放射医学、生物学、药学


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