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 日期:2013-11-26 9:47:28 人气:1020 

马振坤  兼职教授


1980-1984年:北京大学化学系, 学士学位。

1984-1987年:北京大学化学系, 硕士学位。

1987-1991年:美国康涅狄格大学化学系,  博士学位。

1991-1993年:美国波士顿学院化学系, 博士后






Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, Mdluli KE, Franzblau S, Chatterjee AK, Johnson K, Mikusova K, Besra GS, Fütterer K, Jacobs WR Jr, Schultz PG. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci USA. 2013; 110(27): E2510-7.

Hwang JM, Oh T, Kaneko T, Upton AM, Franzblau SG, Ma Z, Cho SN, Kim P. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013; 76(3): 354-67.

Zhang D, Lu Y, Liu K, Liu B, Wang J, Zhang G, Zhang H, Liu Y, Wang B, Zheng M, Fu L, Hou Y, Gong N, Lv Y, Li C, Cooper CB, Upton AM, Yin D, Ma Z*, Huang H*. Identification of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis. J Med Chem. 2012; 55(19): 8409-17.

Liu B, Liu K, Lu Y, Zhang D, Yang T, Li X, Ma C, Zheng M, Wang B, Zhang G, Wang F, Ma Z, Li C, Huang H, Yin D. Systematic evaluation of structure-activity relationships of the riminophenazine class and discovery of a C2 pyridylamino series for the treatment of multidrug-resistant tuberculosis. Molecules. 2012; 17(4): 4545-59.

Blaser A, Palmer BD, Sutherland HS, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Thompson AM, Denny WA. Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824). J Med Chem. 2012; 55(1): 312-26.

Nzila A, Ma Z, Chibale K. Drug repositioning in the treatment of malaria and TB. Future Med Chem. 2011; 3(11): 1413-26.

Upton AM, Ma Z.* New therapeutics in development and future directions, in Current & Emerging Diagnostics, Therapeutics & Vaccines for Tuberculosis, Published by Future Science Group, 2011; Pages 64-77.

Thompson AM, Sutherland HS, Palmer BD, Kmentova I, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6s)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine (PA-824). J Med Chem. 2011; 54(19): 6563-85.

Lu Y, Zheng M, Wang B, Fu L, Zhao W, Li P, Xu J, Zhu H, Jin H, Yin D, Huang H, Upton AM, Ma Z.* Clofazimine analogs with efficacy against experimental tuberculosis and reduced potential for accumulation. Antimicrob Agents Chemother. 2011; 55(11): 5185-93.

A. Zumla, R. Atun, M. Maeurer, P. Mwaba, Z. Ma, J. O’Grady, M. Bates, K.  Dheda, M. Hoelscher, J. Grange. Scientific dogmas, paradoxes and mysteries of latent Mycobacterium tuberculosis infection. Tropical Medicine and International Health. 2011, 16(1): 79–83.

Ma, Z* ; Lienhardt, C; McIlleron, H; Nunn, A. J.; Wang, X. Progress in the Development of a New Generation of Tuberculosis Therapy: Challenegs and Opportunities. Lancet 2010, 375(9731): 2100-9.

Kmentova I, Sutherland HS, Palmer BD, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM. Synthesis and Structure-Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824). J Med Chem. 2010 Nov 11. [Epub ahead of print].

Maroz A, Shinde SS, Franzblau SG, Ma Z, Denny WA, Palmer BD, Anderson RF. Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent. Org Biomol Chem. 2010, 8(2):413-8.

Palmer, Brian D.; Thompson, Andrew M.; Sutherland, H. S.; Blaser, A.; Kmentova, I.; Franzblau, Scott G.; Wang, B.; Wang, Y.; Ma, Z; Denny, W. A. Synthesis and Structure-Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824). J Med Chem. 2010; 53(1): 282-94.

Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Palmer BD, Denny WA, Thompson AM. Synthesis and Structure-activity Relationships of Antitubercular 2-Nitroimidazooxazines Bearing Heterocyclic Side Chains. J Med Chem. 2010, 53(2):855-66.

Ma, Z*; Lienhardt, C. Toward an optimized therapy for tuberculosis? Drugs in clinical trials and in preclinical development. Clin. Chest Med. 2009; 30(4); 755-768.

Ma, Z*; Ginsburg, A.M.; Spigelman, M. Antibacterial: Anti-mycobial Agents. In Comprehensive Medicinal Chemistry II; Taylor, J. B., Triggle, D. Eds.; Elsevier: Oxford, 2007.

Mdluli, K; Ma, Z*.   Mycobacterium tuberculosis DNA gyrase as a target for drug discovery.    Infectious Disorders: Drug Targets  2007,  7(2),  159-168.

Li, Jing; Kim, In Ho; Roche, Eric D.; Beeman, Doug; Lynch, A. Simon; Ding, Charles Z.; Ma, Zhenkun. Design, synthesis, and biological evaluation of BODIPY-erythromycin probes for bacterial ribosomes. Bioorg. Med. Chem. Lett.  2006, 16(4), 794-797.

Keyes, Robert F.; Carter, Justin J.; Zhang, Xiaolin; Ma, Zhenkun.  Short and Efficient Synthesis of a Vinyl-Substituted Tricyclic Erythromycin Derivative. Organic Letters 2005, 7(5), 847-849.

Ma, Zhenkun; Morris, Timothy W.; Combrink, Keith D.  Therapeutic opportunities for the treatment of biofilm-associated infections. Annual Reports in Medicinal Chemistry  2004,  39  197-210.

Gu, Y.; Zhang, X.; Clark, R. F.; Djuric, S. W.; Ma, Z. Tetrahedron Lett. 2004, 45, 3051-3053.

Mitscher, L. A.; Ma, Z. “Structure-Activity Relationships of Quinolone Antimicrobial Agents” in Fluoroquinolone Antibiotics; Low, D.; Ronald, A. R., Eds.; Birkhauser Verlag: Basel, 2003, p11-48.

Nemoto, P. A.; Zhang, X.; Djuric, S. Ma, Z.* “Novel 12-Membered Ring Macrolides with Activity against Erythromycin-Resistant Organisms.” J. Antibiotics. 2003, 56, 392-398.

Keyes, F. R.; Carter, J. J.; Englund, E. E.; Daly, M. M.; Stone, G. G.; Nilius, A. M.; Ma, Z. “Synthesis and Antibacterial Activity of 6-O-Arylbutynyl Ketolides with Improved Activity against Some Key Erythromycin-Resistant Pathogens.” J. Med. Chem. 2003, 46, 1795-1798.

Phan, L. T.; Ma, Z. “Novel Macrolide Derivatives Active against Resistant Pathogens” in Macrolide Antibiotics; Schonfeld, W.; Kirst, H. A., Eds.; Birkhauser Verlag: Basel, 2002, p 141-156.

Nilius A. M.; Ma, Z. “Ketolides: The Future of Macrolides?” Curr. Opin. Pharmacology 2002, 2(5), 493-500.

Ma, Z.;* Li, L.; Rupp, M. J.; Zhang, S.; Zhang, X. “Regio-selective Synthesis of Bifunctional Macrolides as Molecular Probes for Ribosomal Binding Site.”  Org. Lett. 2002, 4(6), 987-990.

Ma. Z.*; Nemoto, P. “Discovery and Development of Ketolides as a New Generation of Macrolide Antimicrobial Agents”. Current Med. Chem. 2002, 1(1), 15-34.

Ma, Z.;* Clark, R. F.; Brazzale, A.; Wang, S.; Rupp, M. J.; Li. L.; Griescraber, G.; Zhang, S.; Yong, H.; Phan, L. T.; Nemoto, P. A.; Chu, D. T. W.; Plattner, J. J.; Zhang, X.; Zhong, P.; Cao, Z.; Nilius, A. M.; Shortridge, V. D.; Flamm, R.; Mitten, M.; Meulbroek, J.; Ewing, P.; Alder, J. Or, Y. S. “Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens.” J. Med. Chem. 2001, 44, 4137-4156.

Ma, Z.;* Florjancic, A. “HMR-3562” Curr. Opin. Anti-Infect. Invest. Drugs 2001, 2(12), 1702-1705.

Phan, L.T.; Clark, R. F.; Rupp, M.; Or, Y. S.; Chu, D. T. W.; Ma, Z. “Synthesis of 2-Fluoro-6-O-propargyl-11,12-carbamate Ketolides. A Novel Class of Antibiotics”. Org. Lett. 2000, 2(19), 2951-2954.

Ma, Z.;* Stenmark, H. G.; Brazzale, A. “Biomimetic Synthesis of Macrolide/Ketolide Metabolites Through a Selective N-Demethylation Reaction” J. Org. Chem. 2000, 65, 3875-3876.

Or, Y. S.; Clark, R. F.; Wang, S.; Chu, D. T. W.; Nilius, A. M.; Flamm, R. K.; Mitten, M.; Ewing, P.; Alder, J.; Ma, Z.* “Design, Synthesis, and Antimicrobial Activity of 6-O-Substituted Ketolides Active Against Resistant Respiratory Tract Pathogens” J. Med. Chem. 2000, 43, 1045.

Ma, Z.;* Clark, R. F.; Nilius S. M.; Flamm, R. K.; Or, Y. Design, Synthesis and Characterization of ABT-773: A Novel Ketolides Highly Active against Multidrug Resistant Pathogens. 5th ICMAS-KO, Serville, Spain. Poster number 02.03 (2000).

Ma, Z.;* Chu, D. T. W.; Cooper, C. S.; et al. “Synthesis and Antimicrobial Activity of  4H-4-O-Oxoquinolizine Derivatives: Consequences of Structural Modification at the C-8 Position” J. Med. Chem. 1999, 42, 4202.

Ma, Z.* “Gemifloxacin” Curr. Opin. Anti-Infect. Invest. Drugs 1999, 1, 493.

Ma, Z.;* Clark, R. F.; Wang, S.; Nilius, A. M.; Flamm, R. K.; Or, Y. Design, Synthesis and Characterization of ABT-773: A Novel Ketolides Highly Active against Multidrug Resistant Pathogens. 39th ICAAC, San Francisco. Poster number 2133 (1999).

Lee, T. B. K.; Goehring, K. E.; Ma, Z.* “One-Step Conversion of Galanthamine to Lycoramine: A Novel Hydride-Transfer Reaction” J. Org. Chem. 1998, 63, 4535.

Ma, Z.;* Wang, S.; Cooper, C.; Fung, A. K. L.; Lynch, J. K.; Plagge, F.; Chu, D. T. W. "Asymmetric Dipolar Cycloaddition Reactions: A Practical, Convergent Synthesis of Chiral Pyrrolidines" Tetrahedron: Asymmetry, 1997, 8, 883.

Kelly, T. R.; Ma, Z. “Tetraacetyl Diborate (TADB)” in Encyclopedia of Reagents for Organic Synthesis; Paquette, L. A., Ed; Wiley: New York, 1995.

Bobbitt, J. M.; Ma, Z. “4-Acetamido-2,2,6,6-tetramethyl-1-piperidinyloxy” in Encyclopedia of Reagents for Organic Synthesis; Paquette, L. A., Ed; Wiley: New York, 1995.

Ma, Z.; Huang, Q.; Bobbitt, J. M. “Oxoammonium Salts 5. A New Synthesis of Hindred Piperidines Leading to Unsymmetrical TEMPO-type Nitroxides; Synthesis of Chiral Nitroxides and Chiral Oxoammonium Salts,” J. Org. Chem. 1993, 58, 4837.

Bobbitt, J. M.; Ma, Z. “Oxoammonium Salts 4. A New Reagent for Phenol Coupling,” Heterocycles 1992, 33, 641.

Ma, Z.; Bobbitt, J. M. “Organic Oxoammonium Salts 3. A New Convenient Method for the Oxidation of Alcohols to Aldehydes and Ketones,” J. Org. Chem. 1991, 56, 6110.


1987 - 美国化学学会

1991 - Phi Beta Kappa荣誉学会会员

1997 - 雅培新药发明主席奖

2001 - 雅培 Volwiler 荣誉学会会员

2003 - 美国科学促进协会

2003 - 美国感染病学会

2005 - 美国微生物学会


美国国立卫生研究院过敏与传染病研究所 (NIH/NIAID) TAACF项目专家评审委员会成员





Current Medicinal Chemistry 任特刊客座总编,负责编辑The Ribosome as an Antibacterial Target 2003年第39期。

中华临床医师杂志 (Chinese Journal of Clinician) 编委会成员 (2011-2014)



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