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葛翠翠


 日期:2018-3-14 12:58:04 人气:2918 

葛翠翠,副教授、硕士生导师

电话:0512-65882263

传真:0512-65884380

电子邮箱:ccge@suda.edu.cn

通讯地址:苏州工业园区仁爱路199, 邮编215123

个人简介:

     2011年获得中科院高能物理研究所博士学位,2012进入苏州大学放射医学与防护学院,2015/02-2016/03,美国食品药品监督管理局,访问学者近年来主要集中于典型纳米材料生物效应及安全应用,取得了阶段性的进展。在毒理学与生物材料领域的国际知名期刊通讯/第一作者发表SCI论文22,包括Proc Natl Acad SciNature comACS NanoNPG Asia MaterSmallNanotoxicologyNanoscaleArch ToxicolACS Appl InterAnal Chem等。发表论文至今被引用>1500次,其中单篇最高他引372,2篇入选ISI web of knowledge-ESIEssential Science Indicators)统计的Highly Cited PapersProc Natl Acad Sci 2011,108:16968; Arch Toxicol 2015,89:519)。

研究方向:

纳米材料在放射医学中的应用

纳米-生物界面相互作用研究

科研项目:

[1] 国家自然科学基金面上项目, 11575123、先进同步辐射技术用于金纳米材料与蛋白质相互作用及相关生物效应研究、2016/01-2019/1273万元、在研、主持。

[2] 参与国家重大研究计划子课题,2014CB931903、纳米特性自适应型载药系统的体内行为、药效与初步安全性评价、2014/01-2018/12142万元、在研、研究骨干。

近五年代表性论著:

Ge Fang#, Weifeng Li#, Xiaomei Shen, Jose Manuel Perez-Aguilar, Yu Chong, Xingfa Gao, Zhifang Chai, Chunying Chen*, Cuicui Ge*, Ruhong Zhou*. Differential Pd-Nanocrystal Facets Demonstrate Distinct Antibacterial Activity against Gram-positive and Gram-negative Bacteria. Nature Communications, 2018, 9

Xiaochuan Ma#, Sangyun Lee#, Xingshu Fei, Ge Fang, Tien Huynh, Yu Chong, Zhifang Chai, Cuicui Ge*, Ruhong Zhou*. Inhibition of the Proteasome Activity by Graphene Oxide Contributes to its Cytotoxicity. Nanotoxicology, 2018, 12(2): 185~200

Yu Chong, Cuicui Ge*, Ge Fang, Renfei Wu, He Zhang, Zhifang Chai, Chunying Chen*, Jun-Jie Yin*. Light-enhanced Antibacterial Activity of Graphene Oxide Mainly via Accelerated Electron Transfer. Environmental Science & Technology 2017, 51:10154-10161.

Ge Fang#, Binquan Luan#, Cuicui Ge*, Yu Chong, Xu Dong*, Jun Guo, Chun Tang, Ruhong Zhou*. Understanding the graphene quantum dots-ubiquitin interaction by identifying the interaction sites." Carbon 2017, 121:285-291.

Xin Tian#, Zaixing Yang#, Guangxin Duan#, Anqing Wu, Zonglin Gu, Leili Zhang, Chunying Chen, Zhifang Chai, Cuicui Ge*, Ruhong Zhou*. Graphene Oxide Nanosheets Retard Cellular Migration via Disruption of Actin Cytoskeleton. Small 2017, 13, 1602133.

Xiaju Cheng, Yuan Yong, Yiheng Dai, Xin Song, Gang Yang, Yue Pan*, Cuicui Ge*. Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment. Theranostics, 2017, 7(17): 4087~4098

Cuicui Ge#, Ge Fang#, Xiaomei Shen, Yu Chong, Wayne G. Wamer, Xingfa Gao*, Zhifang Chai, Chunying Chen*, Jun-Jie Yin*. Facet energy versus enzyme-like activities: the unexpected protection of palladium nanocrystals against oxidative damage. ACS Nano 2016, 10: 10436-10445.

Yu Chong, Cuicui Ge*, Ge Fang, Xin Tian, Xiaochuan Ma, Tao Wen, Wayne G. Wamer, Chunying Chen*, Zhifang Chai, Jun-Jie Yin*. Crossover between Anti-and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light." ACS Nano 2016, 10: 8690-8699.

Yaoyao Deng, Erdong Li, Xiaju Cheng, Jing Zhu, Shuanglong Lu, Cuicui Ge, Hongwei Gu, Yue Pan*, Cuicui Ge*. Facile Preparation of Hybrid Core-shell Nanorods for Photothermal and Radiation Combined Therapy. Nanoscale, 2016, 8(7): 3895~3899.

Guangxin Duan#, Seung-gu Kang#, Xin Tian, Jose Antonio Garate, Zhao Lin, Cuicui Ge*, Ruhong Zhou*. Protein Corona Mitigates the Cytotoxicity of Graphene Oxide by Reducing its Physical Interaction with Cell Membrane., Nanoscale, 2015, 7(37): 15214~15224.

Yu Chong#, Cuicui Ge#, Zaixing Yang#, Jose Antonio Garate, Zonglin Gu, Jeffrey K. Weber, Jiajia Liu, Ruhong Zhou*. Reduced cytotoxicity of graphene nanosheets mediated by blood-protein coating. ACS Nano 2015, 9: 5713-5724.

Xiaju Cheng#, Xin Tian#, Anqing Wu, Jianxiang Li*, Jian Tian, Yu Chong, Zhifang Chai, Yuliang Zhao, Chunying Chen, Cuicui Ge*. Protein corona influences cellular uptake of gold nanoparticles by phagocytic and nonphagocytic cells in a size-dependent manner. ACS Applied Materials & Interfaces, 2015, 7: 20568- 20575.

Zaixing Yang#, Cuicui Ge#, Jiajia Liu, Yu Chong,; Zonglin Gu, Camilo A Jimenez-Cruz, Zhifang Chai, Ruhong Zhou*. Destruction of Amyloid Fibrils by Graphene through Penetration and Extraction of Peptides. Nanoscale, 2015, 7(44): 18725~18737.

Cuicui Ge#, Jian Tian#, Yuliang Zhao, Chunying Chen, Ruhong Zhou, Zhifang Chai*. Towards understanding of nanoparticle-protein corona. Archive of toxicology, 2015, 89(4): 519~539.

Rui Chen#, Lili Zhang#, Cuicui Ge#, Michael T. Tseng, Ru Bai, Ying Qu, Christiane Beer, Herman Autrup, Chunying Chen*. Sub-chronic Toxicity and Cardiovascular Responses in Spontaneously Hypertensive Rats after Exposure to Multiwall Carbon Nanotubes by Intratracheal Instillation. Chemical Research in Toxicology, 2015, 28(3): 440~450.

Jing Zhu, Bin Zhang, Jian Tian, Jiaqing Wang, Yu Chong, Xin Wang, Yaoyao Deng, Minghua Tang, Yonggang Li, Cuicui Ge*, Yue Pan*, Hongwei Gu*. Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging. Nanoscale, 2015, 7(8): 3392~3395.


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