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尚增甫


 日期:2018-3-14 16:46:55 人气:1293 

尚增甫 简历

苏州大学,医学部放射医学与防护学院,副教授,硕士研究生导师

联系方式:

电话:0512-65880065 传真:0512-65884380

电子邮箱:zengfu.shang@suda.edu.cn

通讯地址:苏州工业园区仁爱路199号;邮编:245123

教育经历:

2004/9-2009/7,军事医学科学院,放射与辐射医学研究所,博士

2000/9-2004/7,华中师范大学,生命科学学院,学士

工作经历:

2014/6-至今,苏州大学,医学部放射医学与防护学院,副教授

2012/5-2014/1,美国德州大学西南医学中心,放射肿瘤系,博士后

2011/8-2012/4,美国凯斯西储大学,血液肿瘤系,博士后

2009/12-2011/7,军事医学科学院,放射与辐射医学研究所,博士后

主持或参加科研项目及人才计划项目情况:

项目类别、批准号、名称、研究起止年月、获资助金额、项目状态(已结题或在研等)、主持或参加。

1. 国家自然科学基金青年项目,31500681DNA-PKcs-HDAC6复合物调控放射损伤细胞有丝分裂进程机制研究,2016.01-2018.12,在研,项目负责人,经费24万元;

2. 国家自然科学基金面上项目,81472919DNA-PKcs-FACT信号通路参与DNA损伤诱导的染色质重塑,2015.01-2018.12,在研,项目负责人,经费70万元;

3. 国家自然科学基金面上项目,81071678DNA-PKcsPLK1相互作用偶联DNA修复与细胞有丝分裂调节2011.01-2013.12,已结题,项目负责人,经费31万元。

4. 国家自然科学基金重点项目,81530085DNA-PKcs蛋白翻译后修饰的相互调节及在细胞放射损伤反应中的功能机制研究,2016.01-2020.12,在研,合作单位负责人,分配经费130万元。

代表性论著:

通讯作者论著:

1) Li M*, Li S*, Liu B*, Gu MM, Zou S, Xiao BB, Yu L, Ding WQ, Zhou PK, Zhou J#, Shang ZF#. PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients. J Exp Clin Cancer Res. 2017; 36(1):39.

2) Tian X*, Xiao BB*, Wu A, Yu L, Zhou J, Wang Y, Wang N, Guan H#, Shang ZF#. Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner. Toxicol Res. 2016; 5:1639-48

3) Zou LH, Shang ZF#, Tan Wei, Liu XD, Xu QZ, Song M, Wang Y, Guan H, Zhang SM, Yu L, Zhong CG, Zhou PK#. TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1. Oncotarget. 2015; 6(9):7011-22.

第一及共同第一作者论著:

4) Shang ZF*, Wei Q*, Yu L*, Huang F, Xiao BB, Wang H, Song M, Wang L, Zhou J, Wang J#, Li S#. Suppression of PC-1/PrLZ sensitizes prostate cancer cells to ionizing radiation by attenuating DNA damage repair and inducing autophagic cell death. Oncotarget. 2016; 7(38):62340-51.

5) Shang ZF*, Tan W*, Liu XD*, Yu L, Li B, Li M, Song M, Wang Y, Xiao BB, Zhong CG, Guan H#, Zhou PK#. DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway. Int J Biol Sci. 2015; 11(9):1026-35.

6) Shang Z, Yu L, Lin YF, Matsunaga S, Shen CY, Chen BP#. DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability. Oncogenesis. 2014; 3:e85.

7) Shang ZF*, Yu L*, Li B*, Tu WZ, Wang Y, Liu XD, Guan H, Huang B, Rang WQ, Zhou PK#. 4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1. Cell Cycle. 2012; 11(18):3463-71.

8) Shang ZF*, Huang B*, Xu QZ, Zhang SM, Fan R, Liu XD, Wang Y, Zhou PK#. Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage. Cancer Res. 2010; 70(9):3657-66.

9) Yu L*, Shang ZF*, Abdisalaam S, Lee KJ, Gupta A, Hsieh JT, Asaithamby A, Chen BP#, Saha D#. Tumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments. Nucleic Acids Res. 2016; 44(18):8842-54.

10) Zou S*, Shang ZF*, Liu B, Zhang S, Wu J#, Huang M#, Ding WQ, Zhou J#. DNA polymerase iota (Pol ι) promotes invasion and metastasis of esophageal squamous cell carcinoma. Oncotarget. 2016; 7(22):32274-85.

11) Yu L*, Shang ZF*, Wang J, Wang H, Huang F, Zhang Z, Wang Y, Zhou J#, Li S#. PC-1/PrLZ confers resistance to rapamycin in prostate cancer cells through increased 4E-BP1 stability. Oncotarget. 2015; 6(24):20356-69.

12) Yu L*, Shang ZF*, Hsu FM, Zhang Z, Tumati V, Lin YF, Chen BP, Saha D#. NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor. Oncotarget. 2015; 6(6):3848-60.


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