史海斌，博士生导师、特聘教授
国家杰出青年基金获得者
国家海外高层次人才计划获得者
国家重点研发计划首席青年科学家
江苏省双创人才
电子邮箱：hbshi@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号, 邮编215123
现为苏州大学苏州医学院放射医学与防护学院、放射医学与辐射防护国家重点实验室特聘教授、博士生导师。国家杰出青年科学基金 (2023)、海外高层次人才 (2016) 和江苏省双创人才 (2017) 获得者。曾获教育部高等学校自然科学一等奖、江苏省科学技术二等奖及苏州市医学会医学科技奖一等奖。2003年于雁北师范学院获得学士学位，2006年于苏州大学获得硕士学位，2012年于新加坡国立大学获得博士学位。2012~2014年在美国斯坦福大学医学院从事博士后研究。2014加入苏州大学苏州医学院放射医学与防护学院。研究团队长期致力于智能分子影像探针的构建及在肿瘤等重大疾病诊疗方面研究。在Nat. Comm.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.等杂志发表学术论文80余篇，授权中国发明专利15余项。现兼任中国生物医学工程学会医学影像工程与技术分会、中国核工业教育学会国际交流分会及中国抗癌协会纳米肿瘤学专业委员会委员，国际学术期刊Frontiers in Oncology板块副主编、British Journal of Radiology客座编辑、Proteomics和Proteomics Clinical Applications杂志编委。先后主持国家重点研发专项、基金委杰青、基金委重大研究计划培育项目、面上项目、江苏省重点研发（社发）项目、江苏省高校自然基金重大项目和苏州市科技计划等10余项。
学习/工作经历：
1999-2003年雁北师范学院 本科
2003-2006年苏州大学化学与化工学院 硕士（导师：纪顺俊教授）
2006-2011年新加坡国立大学 博士（导师：Yao Shaoqin教授）
2011-2012年新加坡国立大学 科研助理（合作导师：Liu Bin教授）
2012-2014年美国斯坦福大学 博士后（合作导师：Rao Jianghong教授）
2014年-至今 苏州大学
研究方向：
Ø智能化肿瘤分子探针的构建及生物应用研究
Ø基于多模态多功能分子影像探针的肿瘤诊疗基础研究
Ø放射性药物研发及医学转化
代表性论文：
1.Stimuli-activated Ribonuclease Targeting Chimeras for tumor microenvironment activated cancer therapy.
Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi.*
Nature Commun., 2025, 16, 1288.
2.Self-generative Singlet Oxygen (1O2)-Initiated Chemical Modification of Nuclear DNAs Combats Tumour Drug Resistance.
Anna Wang, Yuqi Zhang, Zhongsheng Zhao, Zhengzhong Lv, Yirui Guo, Miao Li, Yan Chen, Danyang Ji, Xiaju Cheng, Haibin Shi*. J. Am. Chem. Soc. 2025, 147(24), 20534-20547.
3.NIR Light-Mediated Mitochondrial RNA Modification for Cancer RNA Interference Therapeutics.
Yali Feng, Jing Fang, Yan Zhao, Shuyue Ye, Anna Wang, Yuqi Zhang, Jinfeng Zhu, Jiachen Li, Zhengzhong Lv, Zhongsheng Zhao, Haibin Shi.*
Angew. Chem. Int. Ed. 2023, 62(19): e202218969.
4.An Alkaline Phosphatase-Controllable and Red Light-Activated RNA Modification Approach for Precise Tumor Suppression.
Jing Fang, Yali Feng, Yuqi Zhang, Anna Wang, Jiachen Li, Chaoxiang Cui, Yirui Guo, Jinfeng Zhu, Zhengzhong Lv, Zhongsheng Zhao, Chenjie Xu, Haibin Shi.*
J. Am. Chem. Soc. 2022, 144, 23061-23072.
5.A Hydrogen Sulphide-responsive and Depleting Nanoplatform for Cancer Photodynamic Therapy. Yuqi Zhang, Jing Fang, Shuyue Ye, Yan Zhao, Anna Wang, Qiulian Mao, Chaoxiang Cui, Yali Feng, Jiachen Li, Sunao Li, Mingyang Zhang, Haibin Shi*.
Nature Comm., 2022, 13(1): 1685.
6.Aggregation of Gold Nanoparticles Triggered by Hydrogen Peroxide-Initiated Chemiluminescence for Activated Tumor Theranostics.
Qiulian Mao, Jing Fang, Anna Wang, Yuqi Zhang, Chaoxiang Cui, Shuyue Ye, Yan Zhao, Yali Feng, Jiachen Li, Haibin Shi*.
Angew. Chem. Int. Ed., 2021, 60(44): 23805-23811.
7.Red Light-initiated Crosslinking of NIR Probes to Cytoplasmic RNA: An Innovative Strategy for Prolonged Imaging and Unexpected Tumor Suppression
Shuyue Ye, Chaoxiang Cui, Xiaju Cheng, Meng Zhao, Qiulian Mao, Yuqi Zhang, Anna Wang, Jing Fang, Yan Zhao, Haibin Shi*.
J. Am. Chem. Soc. 2020, 142(51), 21502-21512.
8.Quantitatively Visualizing Tumor-Related Protease Activity in Vivo Using a Ratiometric Photoacoustic Probe.
Ling Yin, Hao Sun, Hao Zhang, Lei He, Ling Qiu, Jianguo Lin, Huawei Xia, Yuqi Zhang, Shun-Jun Ji*, Haibin Shi*, and Mingyuan Gao*
J. Am. Chem. Soc. 2019, 141(7), 3265-3273.
9.Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo
Xiaju Cheng, Rui Sun, Ling Yin, Zhifang Chai, Haibin Shi*, and Mingyuan Gao*
Adv. Mater., 2017, 29, 1604894.
10.Engineering Stereochemistry of Cephalosporin for Specific Detection of Metallo-β-Lactamase-Expressing Pathogenic Bacteria
Haibin Shi, Yunfeng Cheng, Kyung Hyun, Lee, Robert F, Luo, Niaz Banaei, and Jianghong Rao*
Angew. Chem. Intl. Ed. 2014, 53(31), 8113-8116.
11.Real-Time Monitoring of Cell Apoptosis and Drug Screening Using Fluorescent Light-Up Probe with Aggregation-Induced Emission Characteristics
Haibin Shi≠, Ryan T. Kwok≠, Jianzhao Liu, Bengang Xing, Benzhong Tang*, and Bin Liu*
J. Am. Chem. Soc., 2012, 134(43), 2073-2084.
12.Specific Detection of Integrin αVβ3 by Light-Up Bioprobe with Aggregation-induced Emission Characteristics
Haibin Shi, Jianzhao Liu, Junlong, Bengang Xing, Benzhong Tang*, and Bin Liu*
J. Am. Chem. Soc., 2012, 134(23), 9569-9572.
13.Cell-Based Proteome Profiling of Potential Dasatinib™ Targets Using Affinity-Based Probes (AfBPs)
Haibin Shi, Chongjing Zhang, Grace Chen, and Shaoqin Yao*
J. Am. Chem. Soc., 2012, 134(6), 3001-3014.