随着核技术在军事、能源以及工、农、医学中的广泛应用，以及新形势下核恐怖发生的可能，放射性核素沾染是核事故时面临的主要问题。放射性物质可以经创面进入人体，造成长期内照射，严重危害人体健康。快速处理放射性核素沾染创面至关重要。传统的液体洗消剂产生大量难以收集处理的放射性废水，导致二次放射性污染。

最近，多模态辐射技术中心胡亮副教授及其合作者崔凤梅教授等人以高分子聚丙烯酰胺，海藻酸钠水凝胶为主要载体，掺入二乙烯三胺五乙酸，报道了一种新型、高效的皮肤伤口去污敷料，具有很好的应该前景。

摘要：Designing skin decontaminating materials with outstanding therapeutic
 effects, adhesiveness, and suitable mechanical property has great practical significance in radionuclide-contaminated skin wound healing. Here, a physically crosslinked hydrogel is constructed via hydrogen bonding of polyacrylamide, sodium alginate (SA), and the complexing agent diethylene triamine pentaacetic acid (DTPA). The physical and chemical properties of the poly(AAm-SA-DTPA) hydrogel (PASD) are detected according to established methods. The decontaminating property and skin wound healing of the PASD are investigated to confirm multi-functions of wound dressing. The physical and chemical properties results show that the synthesis of the PASD hydrogel is effective and that DTPA is present in the hydrogel. The hydrogel also shows great mechanical and swelling properties. In vitro tests find that PASD shows
 significant scavenging abilities for strontium and cerium. In vivo experiments show that the PASD hydrogel can remove radioactive strontium from the skin wounds of mice, and can effectively prevent the absorption of radioactive strontium through the skin wound. Furthermore, the PASD hydrogel can effectively promote the formation of granulation tissue in a radioactive contaminated wound. Taken together, the PASD hydrogels, which has good mechanical properties and radionuclides decontamination, is expected to be used as a dressing for radionuclide-contaminated skin wound healing

相关成果见Feng-Mei Cui, Zhuo-Jun Wu, Rui Zhao, Qiu Chen, Zhi-Yong Liu, Ying Zhao, Hong-Bing Yan, Guo-Liang Shen, Yu Tu, Ding-Hua Zhou, Juan Diwu, Jun Hou, Liang Hu,* and Guo-Jing Wang* Macromol. Biosci. 2021, 2000399. DOI: 10.1002/mabi.202000399