Name: Jinglong Wang
Academic Title/Position: Professor, Doctoral supervisor
Email: jlwang2025@suda.edu.cn
Address: Medical Building 404-4305, North District of Dushu Lake Campus, Soochow University
Contact Phone: +86 (512) 6588 5620
Ⅰ、Educational and Professional Experience
1. Educational Background
2015.09-2019.09 University of Paris (Cité), Cellular & Molecular Biology, Doctor of Science (Supervisor: Terence Strick).
2．Professional Experience
2025.01- Present Suzhou Medical School, Soochow University, Professor
2020.01-2024.12 Stanford University, Department of Radiation Oncology, Postdoc Fellow.
Ⅱ、Research Focus
Both clinical radiotherapy and manned spaceflight involve damage to the body caused by radiation or high-energy particles. At the cellular level, the nuclear genome and mitochondrial genes are highly sensitive to such irradiation, manifesting as complex damage - for example, dozens of DNA double-strand breaks and thousands of single-strand breaks within a single cell, and even more than two lesions within just two supercoils, i.e., clustered damage. DNA serves as the foundation of function and heredity in higher life forms, and its stability is crucial for maintenance. Research on DNA damage repair began in the 1940s, and individual repair pathways are now relatively well understood. However, the repair mechanisms for complex damage - such as competition and coordination among various repair pathways - remain largely unexplored. Our research group is dedicated to following specific aims:
ØElucidating the molecular mechanisms underlying the generation and response to complex damage.
ØUsing single-cell (multi-omics) sequencing to map genomic damage response profiles across different tissues.
ØClarifying how genomic damage and epigenetic modifications interplay with each.
ØInvestigating the long-term effects, transgenerational imprints, and molecular mechanisms following genomic damage.
ØDeveloping radiation bioprotectants and radiosensitizers, including small-molecule drugs.
Ⅲ、Project/Honor/Award
Awards:
1. National Overseas High-level Talent Introduction Program, China, 2025.
2. Jiangsu Province Specially Appointed Professor, China, 2025.
Research projects:
1. National Overseas High-level Talent Introduction Program (HWYQ Program), 2026-2028, x million RMB, Principal Investigator.
2. National Natural Science Foundation of China - General Program, Effects of extreme space environment on genome stability and the underlying molecular mechanisms; Grant number: 82504341; 2026-2028, 300,000 RMB, Principal Investigator.
3. Jiangsu Province Specially Appointed Professor, 2025-2028, 1 million RMB, Principal Investigator.
Ⅳ、Academic Part-time Roles & Student Guidance Outcomes
1. Youth Editorial Member, Journal “Exploration” ;
2. Youth Editorial Member, “Genome Instability and Diesease”;
3. Committee Member, Jiangsu Society of Anatomy
Ⅴ、Recent Five-Year Representative Research Outcomes
1. Wang J, Sadeghi CA, Le LV, Le Bouteiller M, Frock RL. ATM and 53BP1 regulate alternative end joining–mediated V(D)J
recombination. Sci Adv, 2024, 10: eadn4682
2. Wang J, Sadeghi CA, Frock RL. DNA-PKcs suppresses illegitimate chromosome rearrangements. Nucleic Acids Research, 2024, 52:
5048–5066
3. Wang J, Le Gall J, Frock RL, Strick TR. Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex
dissociation. Nat Struct Mol Biol, 2023, 30: 1707–1718
4. Wang JL, Duboc C, Wu Q, et al. Dissection of DNA double-strand-break repair using novel single-molecule forceps. Nat Struct Mol
Biol, 2018, 25: 482–487
5. Öz R, Wang JL, Guerois R, et al. Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA
molecule analysis. Nucleic Acids Research, 2021, 49: 2629–2641
6. Thapar R, Wang JL, Hammel M, et al. Mechanism of efficient double-strand break repair by a long non-coding RNA. Nucleic Acids
Research, 2020, 48: 10953–10972
7. Kostrz D, Wayment-Steele HK, Wang JL, et al. A modular DNA scaffold to study protein–protein interactions at single-molecule
resolution. Nat Nanotechnol, 2019, 14: 988–993
8. Marton T, Wang J, Vaysse A, Yu W, Commere P-H, Holleville Q, et al. Polymerase theta repairs persistent G1-induced DNA breaks
in S-phase during class switch recombination. Nat Commun 2025;16:10536.
9. Libri AB, Wang J, Marton T, Yu W, Dossin F, Balmus G, et al. Senataxin promotes recombination fidelity during antigen receptor
gene diversification. Sci Signal 2025;18:eadv8801.
10. Ji L, Pu L, Wang J, Cao H, Melemenidis S, Sinha S, et al. FTO inhibition enhances the therapeutic index of radiation therapy in
head and neck cancer. JCI Insight 2025;10:e184968.