放射生物学研究中心英文版

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09-15/2026

Recent Three-Year Representative Achievements and Projects

Addressing frontier scientific questions in radiation biology and aligning with major national needs, the center focuses on three primary research directions: "DNA damage repair regulation," "tumor radiation sensitivity," and "normal tissue radioprotection," with a sustained commitment to both basic

Projects Funded in the Past Three Years

No.Approval YearPIGrant No.DurationProject TitleAmount (10,000 CNY)12024Cao Jianping824735652025.01–2028.12Mechanistic study of CERT-mediated sphingolipid metabolic disorder driving macrophage polarization-induced epithelial–mesenchymal transition in radiation-induced pulmonary fibrosis4922024

11-14/2025

PNAS-2025

Recently, a research team led by Professor Lei Chang from the School of Radiation Medicine and Protection at Soochow University, Professor Chunlin Shao from the Institute of Radiation Medicine at Fudan University, and Professor Lingchuan Guo from the First Affiliated Hospital of Soochow University h

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1.    Feng, Y. et al. Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury. Experimental and Molecular Medicine 56, 1107-1122, doi:10.1038/s12276-024-01208-z (2024).
2.    Geng, F. H. et al. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cellular & molecular immunology 21, 856-872, doi:10.1038/s41423-024-01185-3 (2024).
3.    Geng, F. H. et al. A Frog Skin-Derived Peptide Targeting SCD1 Exerts Radioprotective Effects Against Skin Injury by Inhibiting STING-Mediated Inflammation. Adv Sci 11, doi:10.1002/advs.202306253 (2024).
4.    Ji, M. T. et al. Mechano-YAP/TAZ-regulated smooth muscle cells are an important source of Wnt signalling for gut regeneration. Clin Transl Med 14, doi:ARTN e7000510.1002/ctm2.70005 (2024).
5.    Shu, Y. Y. et al. Ku70 Binding to YAP Alters PARP1 Ubiquitination to Regulate Genome Stability and Tumorigenesis. Cancer Res. 84, 2836-2855, doi:10.1158/0008-5472.Can-23-4034 (2024).
6.    Tang, Y. T. et al. USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling. Int. J. Radiat. Oncol. Biol. Phys. 119, 1261-1274, doi:10.1016/j.ijrobp.2024.01.220 (2024).
7.    Wang, P. et al. Vitamin D receptor attenuates carbon tetrachloride-induced liver fibrosis via downregulation of YAP. J Hazard Mater 478, doi:ARTN 13548010.1016/j.jhazmat.2024.135480 (2024).
8.    Yin, X. H. et al. Rational Design of Dual-Functionalized Gd@C82 Nanoparticles to Relieve Neuronal Cytotoxicity in Alzheimer's Disease via Inhibition of Aβ Aggregation. ACS nano 18, 15416-15431, doi:10.1021/acsnano.3c08823 (2024).
9.    Xie, L. W. et al. Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics. Gut Microbes 16, doi:Artn 234772210.1080/19490976.2024.2347722 (2024).
10. Xie, L. W. et al. Probiotic Consortia Protect the Intestine Against Radiation Injury by Improving Intestinal Epithelial Homeostasis. Int. J. Radiat. Oncol. Biol. Phys. 120, 189-204, doi:10.1016/j.ijrobp.2024.03.003 (2024).