姓 名：焦旸
职称/职务：教授/中心副主任
电子邮箱：jiaoyang@suda.edu.cn
办公地址：独墅湖北区医学楼402-2305
一、学习工作经历
1、学历背景：
2004.9-2007.6 苏州大学，放射医学与公共卫生学院，医学博士
1996.9-2001.6 东南大学，医学院，医学学士
2、工作经历：
2007.8-至今苏州大学，放射医学与防护学院，讲师、副教授、教授
二、研究方向
1、正常组织辐射损伤分子机制研究：从肿瘤微环境的角度阐释异常脂代谢产物对肿瘤放疗敏感性的影响及分子机制。
2、肿瘤放射敏感性的分子调控机理：从表观遗传学修饰调控网络的角度揭示肝脏、肺、肠等正常组织发生辐射损伤的分子机理
三、项目、荣誉和奖励
1、国家自然科学基金-面上项目，Rac1跨细胞激活UBC9介导的SUMO化修饰促进放射性肺纤维化的机制及干预策略，82574020，47万元，2026.01-2029.12。
2、放射医学协同创新中心内部协作课题，靶向Rac1的肝癌精准放免综合治疗应用基础研究，FY202401, 50万元，2025.04-2027.03。
3、四川省放射与治疗临床医学研究中心开放课题, Sirt6/CERT/鞘脂代谢通路调控细胞间对话促进放射性肺纤维化的机制研究，2024ZX01，20万元，202501-2027.12.31。
4、国家卫生健康委核技术医学转化重点实验室开放课题，靶向去泛素化调控通路精准干预放射性肺损伤的策略研究，2023HYX005, 10万元，2024.01-2026.12。
5、省部共建“放射医学与防护”国家重点实验室创新项目，多维度低剂量辐射量-效关系模型的构建及验证，GZC00402，50万元，2022.11-2023.10。
四、学术兼职、指导学生成果等
担任中华医学会放射医学与防护学分会委员，中国毒理学会放射毒理学分会委员，中国抗癌协会肿瘤微生态分会青年委员，江苏省研究型医院学会放射医学专业委员会常务委员；至今指导硕/博士研究生18人，毕业生就业率100%。
五、近五年代表性研究成果
1、Yang Jiao#, Jiawei Ren#, Shichang Xie#, Nan Yuan, Jiaqi Shen, Huafang Yin, Jian Wang, Hongjuan Guo, Jianping Cao, Xin Wang, Depei Wu*, Zhemin Zhou*, Xiaofei Qi*. Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway, Gut Microbes, 2025, 17(1): 2488105.
2、Yang Feng, Lirong Zhang, Youbin Zhang, Ying Xu, Kaixiao Zhou, Zhao Yang, Wei Zhu, Qi Zhang, Jianping Cao, Lili Wang*, Yang Jiao*. NEDD4-Mediated Endothelial-Mesenchymal Transition Participates in Radiation-Induced Lung Injury Through the ATM Signaling Pathway, Dose Response, 2025, 23(2):15593258251352726.
3、Yiting Tang, Tingya Wang, Liming Gu, Ying Xu, Zhao Yang, Wei Zhu, Qi Zhang, Judong Luo, Jianping Cao*, Yang Jiao*. USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling, International Journal of Radiation Oncology · Biology · Physics, 2024, 119(4):1261-1274. doi.org/10.1016/j.ijrobp.2024.01.220.
4、YiDi Wang, Dong Kong, Han Gao, ChuanSheng Du, HuiYuan Xue, Kun Liu, XiangHui Kong, WenYue Zhang, YuChen Yin, Tao Wu, Yang Jiao*, Liang Sun*. Multiple Mesh-type Real Human Cell Models for Dosimetric Application Coupled with Monte Carlo Simulations, Radiat Res, 2023, 200(2):176-187.
5、Yang Feng, Ping Yuan, Hongjuan Guo, Liming Gu, Zhao Yang, Jian Wang, Wei Zhu, Qi Zhang, Jianping Cao, Lili Wang*, Yang Jiao*. METTL3 Mediates Epithelial-Mesenchymal Transition by Modulating FOXO1 mRNA N6 -Methyladenosine-Dependent YTHDF2 Binding: A Novel Mechanism of Radiation-Induced Lung Injury, Adv Sci (Weinh),2023, 10(17):e2204784.
6、Rongrong Wang#, Depei Wu#, Jianfeng Dai#, Jiaqi Shen, Jianjie Rong, Zixing Chen, Yang Jiao*, Xiaofei Qi*. USP11 plays a critical role in the onset and progression of acute graft-versus-host disease：Novel target for precision therapeutics, Pharmacological Research, 2023,189:106707.
7、Hengzhao Zhuang#, Bo Yu#, Dan Tao#, Xiaoyan Xu, Yijun Xu, Jian Wang*, Yang Jiao*, Lili Wang*. The role of m6A methylation in therapy resistance in cancer, Molecular Cancer, 2023,22:91.
8、Yang Jiao, Jing Xu, Bin Song, Ailing Wu, Lu Pan, Ying Xu, Fenghao Geng, Xiaoqian Li, Congzhao Zhao, Min Hong, Xuanyu Meng, Judong Luo, Pengfei Liu, Ming Li, Wei Zhu, Jianping Cao*, Shuyu Zhang*. Interferon regulatory factor 1-triggered free ubiquitin protects the intestines against radiation-induced injury via CXCR4/FGF2 signaling, MedComm, 2022, 3:e168.
9、Yiting Tang#, Qian Yuan#, Congzhao Zhao, Ying Xu, Qi Zhang, Lili Wang, Zhiqiang Sun, Jianping Cao, Judong Luo*, Yang Jiao*. Targeting USP11 may alleviate radiation-induced pulmonary fibrosis by regulating endothelium tight junction, International Journal of Radiation Research, 2022,98(1):30-40.
10、Lihuan Wang, Congzhao Zhao, Haoru Shan, Yang Jiao*, Qi Zhang, Xiaoran Li*, Jianyong Yu, and Bin Ding*. Deoxycholic acid-modified microporous SiO2 nanofibers mimicking colorectal microenvironment to optimize radiotherapy-chemotherapy combined therapy, Biomedical Materials, 16 (2021) 065020.