姓 名：畅磊
职称/职务：教授
电子邮箱：changlei@suda.edu.cn
办公地址：独墅湖北区医学楼402-2220
一、学习工作经历
1、学历背景：
2013.01-2015.12 帕多瓦大学，分子医学学院，理学博士
2005.09-2009.07 吉林大学，理学学士
2、工作经历：
2019.01-至今苏州大学，放射医学与防护学院，教授
2016.01-2018.12 帕多瓦大学，分子医学学院，Research Fellow
二、研究方向
2.新型放疗技术的生物学研究。
3.Hippo 信号通路在肿瘤发生中的作用。
三、项目、荣誉和奖励
1.国家海外高层次人才;
2.江苏省杰青;
3.江苏省特聘教授;
5.教育部霍英东教育基金会-青年基金，2020至2023，18万，主持，已结题。
四、学术兼职、指导学生成果等
1.江苏省毒理学会放射毒理专业委员会-副主任委员
2.中国抗癌协会肿瘤转移专业委员会-委员；
3.中国生理学会基质生物学专业委员会委员;
4.中国生物物理学会环境与辐射生物物理分会-青年委员；
5.中国生物物理学会代谢生物学分会-青年委员；
6.江苏省预防医学会放射医学与防护委员会-委员。
7.“Military Medical Research”编委(IF=16.7，入选中国科技期刊卓越行动计划) 。
8.《国际放射医学核医学杂志》编委。
五、近五年代表性研究成果
1.Chang L#, Azzolin L#, Di Biagio D#, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M*, Piccolo S*. The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature (2018). Nov;563(7730):265-269. (第一作者，IF=43, 顶刊，该论文收载于国际F1000数据库)
2.Mintao Ji#, Dongsheng Chen#, Yinyin Shu, Shuai Dong, Zhisen Zhang, Haimeng Zheng, Xiaoni Jin, Lijun Zheng, Yang Liu, Yifei Zheng, Wensheng Zhang, Shiyou Wang Guangming Zhou, Bingyan Li, Baohua Ji, Yong Yang*, Yongde Xu*, Lei Chang*.The Role of Mechanoregulated YAP/TAZ in Erectile Dysfunction.Nature Communications. 2023;14:3758.doi.org/10.1038/s41467-023-39009-z (*通讯作者，IF=16.6, 中科院1区top期刊)
3.Yinyin Shu#, Xiaoni Jin#, Mintao Ji#, Zhisen Zhang, Xiuxiu Wang, Haisheng Liang, Shuangshuang Lu, Shuai Dong, Yiping Lin, Yuhan Guo, Qiuyu Zhuang, Yuhong Wang, Zhe Lei, Lingchuan Guo, Xuanyu Meng, Guangming Zhou, Wensheng Zhang, Lei Chang*. Ku70 Binding to YAP Alters PARP1 Ubiquitination to Regulate Genome Stability and Tumorigenesis. Cancer Research, 2024 Sep 4;84(17):2836-2855. doi: 10.1158/0008-5472.CAN-23-4034. (*独立通讯作者，IF=16.6, 中科院1区top期刊)
4.Luo Chenyu#, Haisheng Liang#, Mintao Ji, # Caiyong Ye#, Yiping Lin, Yuhan Guo, Zhisen Zhang，Yinyin Shu, Xiaoni Jin, Shuangshuang Lu, Wanling Lu, Yazheng Dang, Hong Zhang, Bingyan Li, Guangming Zhou, Zengli Zhang*, Lei Chang*. 2025. Autophagy Induced by Mechanical Stress Sensitizes Cells to Ferroptosis by the NCOA4-FTH1 Axis. Autophagy, 2025, February. doi:10.1080/15548627.2025.2469129. (*通讯作者，IF=14.6 中科院1区top期刊)
5.Ji M#, Dong S#, Lu S, Liang H, Lin Y, Luo C, Zheng H, Shu Y, Zhang Z, Jin X, Guo Y, Kang K, Zhang H, Wang Y, Sladitschek-Martens HL, Huang S, Fu X, Zhou G*, Wen Z*, Chang L*. Mechano-YAP/TAZ-regulated smooth muscle cells are an important source of Wnt signalling for gut regeneration. Clin Transl Med. 2024 Aug;14(8):e70005. doi: 10.1002/ctm2.70005. PMID: 39152676. (*通讯作者，IF=7.9, 中科院1区top期刊)
6.Wang P#, Li J#, Ji M#, Pan J, Cao Y, Kong Y, Zhu L, Li J, Li B*, Chang L*, Zhang Z*. Vitamin D receptor attenuates carbon tetrachloride-induced liver fibrosis via downregulation of YAP. J Hazard Mater. 2024 Aug 10;478:135480. doi: 10.1016/j.jhazmat.2024.135480. PMID: 39146589. (*通讯作者，IF=12.2, 中科院1区top期刊)
7.Lijun Zheng#, Chenyu Luo#, Nan Yang, Hailong Pei, Mintao Ji, Yinyin Shu, Zhisen Zhang, Shuai Dong, Xiuxiu Wang, Xuemei Li, Wensheng Zhang, Yan Wang, Bingyan Li, Tom Hei*, Guangming Zhou*, Lei Chang*. Ionizing Radiation-induced Long Non-coding RNA CRYBG3 regulates YAP/TAZ through Mechanotransduction. Cell Death & Disease. 2022. (*通讯作者，IF=9.6, 中科院1区top期刊)
8.Ying Ye#, Wenyan Xie#, Xuepeng Wang#, Shuping Tan, Lingyue Yang, Zhaoru Ma, Zhexin Zhu, Xi Chen, Xiaoyu Liu, Eric O'Neill*, Lei Chang*, Wensheng Zhang*. DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells. Cell Mol Life Sci. 2025 Jan 6;82(1):38. doi: 10.1007/s00018-024-05561-0. PMID: 39762370. (*通讯作者，IF=6.2, 中科院2区top期刊)
9.Ying Ye#, Wenyan Xie#, Zhaoru Ma#, Xuepeng Wang, Yi Wen, Xuemei Li, Hongqian Qi, Hao Wu, Jinnan An, Yan Jiang, Xinyi Lu, Guokai Chen, Shijun Hu*, Elizabeth A Blaber, Xi Chen*, Lei Chang*, Wensheng Zhang*. Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat. Cell Death Discovery. 2024 Feb 9;10(1):68. doi: 10.1038/s41420-024-01846-2. (*通讯作者，IF=7, 中科院2区)