李明

作者: 发布时间:2025-09-19 浏览次数:12

姓  名:李明

职称/职务:副教授

电子邮箱:lim1984@suda.edu.cn                                                          



一、学习工作经历

1、学历背景:

2005.9-2010.7  军事医学科学院,放射与辐射医学研究所,理学博士

2001.9-2005.7  内蒙古农业大学,生命科学学院,工学学士

2、工作经历:

2010.8-至今苏州大学,放射医学与防护学院,讲师、副教授


二、研究方向

1、放射性肠损伤的机制及救治研究

2、消化道肿瘤的放射增敏研究

3、空间辐射损伤效应与防护


三、项目、荣誉和奖励

1、国家自然科学基金-面上项目,线粒体动力学平衡调控肠道干细胞铁死亡在放射性肠损伤中的作用及机制研究,8247357849万元,2025.01-2028.12

2、国家自然科学基金-面上项目,PIG3-DNA-PKcs信号通路调控电离辐射诱发的有丝分裂灾变机制研究,8167309155万元,2017.01-2020.12

3、国家自然科学基金-青年项目,KLF5在放射性肠损伤中的作用及机制研究,3130069422万元,2014.01-2026.12

4、田野, 李明, 蔡尚, 郭旗, 赵培峰, 徐加英, 彭啟亮, 钱建军, 孙彦泽. 肠道辐射损伤诊治新技术的研发与应用. 国防科技进步奖二等奖. 2024

5、田野, 李明, 蔡尚, 郭旗, 赵培峰, 钱建军, 彭啟亮. 放射性肠损伤诊治新技术的研发与应用. 江苏医学科技奖三等奖. 2023


四、学术兼职、指导学生成果等

Radiation Medicine and Protection》青年编委

江苏省预防医学会放射医学与防护专业委员会委员

中国老年医学学会基础与转化医学分会第二届委员会委员

指导两名硕士生获得苏州大学优秀硕士学位论文

协助指导硕士博士生获国家奖学金、优秀毕业研究生等荣誉称号


五、近五年代表性研究成果

1Tang LF*, Tang FL*, Zhou H*, Li ZK, Pi CQ, He Y#, Li M#. Bacillus Coagulans BC99 Protects Ionizing Radiation-Induced Intestinal Injury and Modulates Gut Microbiota and Metabolites in Mice. Mol Nutr Food Res. 2025;69(11):e70057.

2Xie LW*, Cai S*, Lu HY, Tang FL, Zhu RQ, Tian Y#, Li M#. Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics. Gut Microbes. 2024; 16(1): 2347722.

3Xie LW*, Lu HY*, Tang LF*, Tang FL, Zhu RQ, Wang DF, Cai S, Tian Y#, Li M#. Probiotic Consortia Protect the Intestine Against Radiation Injury by Improving Intestinal Epithelial Homeostasis.Int J Radiat Oncol. 2024;120(1):189-204.

4Lu H*, Xie L*, Guo L*, Gu X, Zhu R, Yang Y, Tang F, Li M, Liu C, Wang D, Li M#, Tian Y#, Cai S#. EGCG protects intestines of mice and pelvic cancer patients against radiation injury via the gut microbiota/D-tagatose/AMPK axis. Radiother Oncol. 2024;202:110608.

5Tang FL*, Xie LW*, Tang LF*, Lu HY, Zhu RQ, Wang DF, Tian Y#, Cai S#, Li M#. Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo. Int Immunopharmacol. 2024; 129: 111637.

6Xu J*, He J*, Zhou YL, Weng Z, Li M#, Wang ZX#, He Y#. Von Willebrand factor promotes radiation-induced intestinal injury (RIII) development and its cleavage enzyme rhADAMTS13 protects against RIII by reducing inflammation and oxidative stress. Free Radic Biol Med. 2024; 210: 1-12.

7Tang LF*, Ma X*, Xie LW*, Zhou H, Yu J, Wang ZX#, Li M#. Perillaldehyde Mitigates Ionizing Radiation-Induced Intestinal Injury by Inhibiting Ferroptosis via the Nrf2 Signaling Pathway. Mol Nutr Food Res. 2023; 67(19): e2300232.

8Zhou H*, Zhou YL*, Mao JA*, Tang LF, Xu J, Wang ZX#, He Y#, Li M#. NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells. Redox Biol. 2022 Jul 30;55:102413.

9Cai S*, Xie LW*, Xu JY*, Zhou H, Yang C, Tang LF, Tian Y#, Li M#. (-)-Epigallocatechin-3-Gallate (EGCG) Modulates the Composition of the Gut Microbiota to Protect Against Radiation-Induced Intestinal Injury in Mice. Front Oncol. 2022 Apr 11;12:848107.

10Zhao TS*, Xie LW*, Cai S*, Xu JY, Zhou H, Tang LF, Yang C, Fang S, Li M#, Tian Y#. Dysbiosis of Gut Microbiota Is Associated With the Progression of Radiation-Induced Intestinal Injury and Is Alleviated by Oral Compound Probiotics in Mouse Model. Front Cell Infect Microbiol. 2021; 11: 717636.