杨光保，教授、博士生导师

电子邮箱：yangguangbao@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号，邮编215123



个人简历：杨光保，苏州大学放射医学与防护学院教授，博士生导师。入选江苏省优秀青年基金、江苏省“333工程”高层次人才培养计划、姑苏创新创业青年领军人才项目。2017年毕业于苏州大学获得博士学位（导师：刘庄教授），2017年至2019年在新加坡南洋理工大学进行博士后研究（导师：赵彦利教授）。2020年加入苏州大学苏州医学院放射医学与防护学院，当前主要围绕生物材料构建与增效肿瘤放射免疫治疗等方面开展相关工作。迄今为止在化学、材料以及生物医学等多种国际高水平期刊上发表SCI学术论文40余篇，其中多篇以第一/通讯作者发表于Nat. Commun.、Adv. Mater.、Nano Lett.、ACS Nano、Adv. Funct. Mater.、Nano Today、Coord. Chem. Rev.、Small、Biomaterials等期刊。论文总他引次数超过7000余次，高被引论文8篇，H-index:35。担任Radiat. Med. Prot.、Nano Res.、Aging Dis.、View等期刊青年编委。2021-2024年连续入选全球前2%顶尖科学家年度影响力榜单。


研究方向：

  1. 生物微环境响应药物递送系统的开发与应用

  2. 功能性纳米材料在肿瘤微环境调控与肿瘤治疗中的应用

  3. 生物材料在肿瘤放射免疫治疗中的应用探索


科研项目：

  1. 国家自然科学基金面上项目，肿瘤微环境响应性多氧钨酸盐复合材料的构建及放射免疫治疗研究，2024.01-2027.12，50万元，主持；

  2. 江苏省优秀青年基金项目，多不饱和脂肪酸纳米胶束构建及肿瘤放射免疫治疗研究，2024.09-2027.08，50万元，主持；

  3. 国家自然科学基金青年项目，肿瘤微环境响应性二氧化锰纳米复合物的构建及其用于肿瘤免疫治疗的研究，2021.01-2023.12，24万元，主持；

  4. 姑苏创新创业青年领军人才项目，天然高分子水凝胶载体构建及其在肿瘤微环境多重调控与放射免疫治疗中的应用，2022.07-2025.06，50万元，主持；

  5. 苏州医学院基础前沿创新交叉项目，免疫调节佐剂构建与增效放射免疫治疗研究，2023.10-2025.09，50万元，主持。


代表性论著：

  1. Xirui Wu, Junjun Zhang, Zheng Deng, Xianglong Sun, Yifan Zhang, Cai Zhang, Jiadong Wang, Xinke Yu,Guangbao Yang*,“Bacteria-based biohybrids for remodeling adenosine-mediated immunosuppression to boost radiotherapy-triggered antitumor immune response”,Biomaterials 2025, 316:123000.

  2. Jiadong Wang, Yueyue Jing, Li Liu, Pengfei Xing, Zheng Deng, Yifan Zhang, Xirui Wu, Bin Hu, Cai Zhang, Xianglong Sun, Yuqian Liu, Jiawei Liu*, Junjun Zhang*,Guangbao Yang*,“Self-Assembled arachidonic acid Nanomicelles for Radiation-Induced ferroptosis to enhance tumor Radioimmunotherapy”,Chem. Eng. J.2025, 507:160231.

  3. Kangzhi Yuan, Cai Zhang, Xinlu Pan, Bin Hu, Junjun Zhang*,Guangbao Yang*,“Immunomodulatory metal-based biomaterials for cancer immunotherapy”,J. Control. Release2024,375:249-268.

  4. Min Xi, Zheng Deng, Cai Zhang, Xirui Wu, Lin Zhang, Yifan Zhang, Xianglong Sun, Jinhua Zhou*,Guangbao Yang*,“FeS-based cascade bioreactors driven by Shewanella oneidensis MR-1 for efficient chemodynamic therapy with augmented antitumor immunity”,Nano Today 2024, 55:102165.

  5. Zheng Deng, Min Xi, Cai Zhang, Xirui Wu, Quguang Li, Chunjie Wang, Huapan Fang, Guanting Sun, Yifan Zhang,Guangbao Yang*, Zhuang Liu*,“Biomineralized MnO2 Nanoplatforms Mediated Delivery of Immune Checkpoint Inhibitors with STING Pathway Activation to Potentiate Cancer Radio-Immunotherapy”,ACS Nano 2023, 17, 4495-4506.ESI高被引论文

  6. Zheng Deng, Jiawei Liu, Min Xi, Chunjie Wang, Huapan Fang, Xirui Wu, Cai Zhang, Guanting Sun, Yifan Zhang, Lin Shen, Minjiang Chen, Jiansong Ji*, Zhuang Liu*,Guangbao Yang*,“Biogenic platinum nanoparticles on bacterial fragments for enhanced radiotherapy to boost antitumor immunity”,Nano Today 2022, 47:101656.

  7. Guangbao Yang, Dongdong Wang, Soo Zeng Fiona Phua, Anivind Kaur Bindra, Cheng Qian, Rui Zhang, Liang Cheng, Guofeng Liu, Hongwei Wu, Zhuang Liu,* Yanli Zhao*,“Albumin-Based Therapeutics Capable of Glutathione Consumption and Hydrogen Peroxide Generation for Synergetic Chemodynamic and Chemotherapy of Cancer”,ACS Nano 2022, 16, 2319-2329.

  8. Guangbao Yang, Soo Zeng Fiona Phua, Wei Qi Lim, Rui Zhang, Liangzhu Feng, Guofeng Liu, Hongwei Wu, Anivind Kaur Bindra, Deblin Jana, Zhuang Liu,* and Yanli Zhao*,“A Hypoxia-Responsive Albumin-Based Nanosystem for Deep Tumor Penetration and Excellent Therapeutic Efficacy”,Adv. Mater.2019; 31, 1901513.ESI高被引论文

  9. Guangbao Yang, Soo Zeng Fiona Phua, Anivind Kaur Bindra, and Yanli Zhao*,“Degradability and Clearance of Inorganic Nanoparticles for Biomedical Applications”,Adv. Mater.2019; 31, 1805730.ESI高被引论文

  10. Guangbao Yang, Ligeng Xu, Jun Xu, Rui Zhang, Guosheng Song, Yu Chao, Liangzhu Feng, Fengxuan Han, Ziliang Dong, Bin Li,* and Zhuang Liu*,“Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer”,Nano Lett. 2018; 18, 2475-2484.ESI高被引论文

  11. Guangbao Yang, Rui Zhang, Chao Liang, He Zhao, Xuan Yi, Sida Shen, Kai Yang, Liang Cheng, Zhuang Liu*,“Manganese Dioxide Coated WS2@Fe3O4/sSiO2 Nanocomposites for pH-Responsive MR Imaging and Oxygen-Elevated Synergetic Therapy”,Small2018; 14, 1702664.

  12. Guangbao Yang‡, Ligeng Xu‡, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, Zhuang Liu*,“Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses”,Nat. Commun. 2017; 8, 902.ESI高被引论文

  13. Guangbao Yang, Xiaoqi Sun, Jingjing Liu, Liangzhu Feng, and Zhuang Liu*,“Light-Responsive, Singlet Oxygen-Triggered On-Demand Drug Release from Photosensitizer-Doped Mesoporous Silica Nanorods for Cancer Combination Therapy”,Adv. Funct. Mater. 2016; 26, 4722-4732.

  14. Guangbao Yang, Jingjing Liu, Yifan Wu, Liangzhu Feng*, Zhuang Liu*,“Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment”,Coord. Chem. Rev. 2016; 320, 100-117.

  15. Guangbao Yang, Hua Gong, Teng Liu, Xiaoqi Sun, Liang Cheng, Zhuang Liu*,“Two-dimensional magnetic WS2@Fe3O4nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer”,Biomaterials 2015; 60:62-71.

  16. Guangbao Yang, Hua Gong, Xiaoxin Qian, Pengli Tan, Zhiwei Li, Teng Liu, Jingjing Liu, Youyong Li*, and Zhuang Liu*,“Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer”,Nano Res. 2015; 8:751-64.


专利：

  1. 刘庄，杨光保，一种空心MnO2复合纳米材料、其制备方法及其应用，2020-01-17， 中国，ZL201710618202.6；

  2. 杨光保，孙相龙，一种细菌外膜囊泡为模板的氢氧化铝纳米颗粒及其制备方法和应用，2023-12-22，中国，202311780036.1；

  3. 杨光保，王家栋，胡彬，一种由氨基酸制备的花生四烯酸胶束及其制备方法和应用，2024-01-09，中国，202410031470.8；

  4. 杨光保，邓正，刘宇骞，武西瑞，一种杂多酸/生物多胺自组装晶体及其制备方法与应用，2024-04-30，中国，2024043002437730；

  5. 杨光保，张彩，刘秧，一种层状双金属氢氧化物纳米片及其制备方法与应用，2024-07-18，中国，2024071800730630。


课程教学及招生信息：

本课题组热忱欢迎具有化学、材料学、生物学及医学背景的本科生/硕士生/博士生以及博士后到课题组学习工作。有疑问请随时邮件联系yangguangbao@suda.edu.cn。