闻刚，博士生导师、特聘教授、国家级青年人才

办公室：401-1219

电子邮箱：gangwen@suda.edu.cn

通讯地址：苏州工业园区仁爱路199号，邮编215123


个人简介：

闻刚，苏州大学特聘教授，博士生导师，国家级青年人才。本科毕业于天津医科大学，硕士毕业于清华大学-北京协和医学院，导师为吴松研究员。博士毕业于比利时荷语鲁汶大学，师从欧洲科学院院士Johan Hofkens教授。博士毕业后，先后在比利时荷语鲁汶大学和德国维尔茨堡大学从事博士后研究，合作导师分别为Johan Hofkens教授与知名超分辨成像领域专家、dSTORM开发者Markus Sauer教授。主要从事多功能靶向荧光探针设计、膨胀显微成像及其在生物医学成像中的应用等领域。在相关研究领域，以第一作者或通讯作者身份(含共同)在Chem. Rev.、J. Am. Chem. Soc.、ACS Nano、Aggregate、Eur. J. Med. Chem.等国际知名期刊发表SCI论文11篇；申请中国发明专利1项(授权)、欧洲专利2项；所研发的多功能TRITON探针已实现商业化(Chrometra公司)。


研究方向：

  • 新型多功能荧光探针的开发及应用

  • 基于膨胀水凝胶的超分辨成像策略开发与应用

  • 膜蛋白与其治疗性抗体的作用机制

  • 放射性药物开发与评估


代表性论著：

1.  Wen, G., Leen, V., Rohand, T., Sauer, M., Hofkens, J.Current Progress in Expansion Microscopy: Chemical Strategies and Applications.Chem. Rev., 2023, 123(6), 3299-3323.

2. Wen, G.#, Chen, X., Eiring, P., Leen, V., Hofkens, J., Sauer, M.# Functionalized docetaxel probes for refined visualization of mitotic spindles by expansion microscopy.J. Am. Chem. Soc. 2025, 147(8), 6604-6611. (#Corresponding authors).

3. Wen, G., Vanheusden, M., Leen, V., Rohand, T., Vandereyken, K., Voet, T., Hofkens, J. A Universal Labeling Strategy for Nucleic Acids in Expansion Microscopy.J. Am. Chem. Soc., 2021, 143(34), 13782-13789.

4. Wen, G., Lycas, M. D., Jia, Y., Leen, V., Sauer, M., Hofkens, J.Trifunctional linkers enable improved visualization of actin by expansion microscopy.ACS Nano, 2023, 17(20), 20589-20600.

5. Wen, G.§, Vanheusden, M.§, Acke, A.§, Valli, D., Neely, R. K., Leen, V., Hofkens, J. Evaluation of direct grafting strategies via trivalent anchoring for enabling lipid membrane and cytoskeleton staining in expansion microscopy.ACS Nano, 2020, 14(7), 7860-7867.

6. Wen, G.#, Helmerich, D., Behringer-Pließ, L., Sauer, M.# A multifunctional probe for nanoscale visualization and tracking of cholesterol in cells.Aggregate, 2025, 6(8), e70104 (#Corresponding authors).

7. Zhang, G.§, Liang, J.§,Wen, G.§, Yao, M., Jia, Y., Feng, B., Li, J., Han, Z., Liu, Q., Li, T., Zhang, W., Jin, H., Xia, J., Peng, L., Wu, S. Discovery of novel 1, 4-dicarbonylthiosemicarbazides as DNA gyrase inhibitors for the treatment of MRSA infection.Eur. J. Med. Chem., 2024, 116905.

8. Wen, G., Leen, V., Jia, Y., Rohand, T., Hofkens, J.Improved Dye Survival in Expansion Microscopy through Stabilizer‐Conjugated Linkers.Chem. Eur. J., 2022, 28(66), e202202404.

9. Li, T.§,Wen, G.§, Li, J., Zhang, W., Wu, S. A useful synthesis of 2-acylamino-1, 3, 4-oxadiazoles from acylthiosemicarbazides using potassium iodate and the discovery of new antibacterial compounds.Molecules, 2019, 24(8), 1490.

10. Wen, G., Zhang, W. X., Wu, S. A novel synthesis of 4-acetoxyl 5(4H)-oxazolones by direct α-oxidation of N-benzoyl amino-acid using hypervalent iodine.Molecules, 2017, 22(7), 1102.

11. Wen, G.§, Liu, Q.§, Hu, H., Wang, D., Wu, S. Design, synthesis, biological evaluation, and molecular docking of novel flavones as H3R inhibitors.Chem. Biol. Drug Des., 2017, 90(4), 580-589.