程侠菊,苏州大学副教授,硕士生导师,
电话:15106131597
电子邮箱:xjcheng@suda.edu.cn
通讯地址:苏州工业园区仁爱路199号,邮编215123
个人简历
程侠菊,苏州大学副教授,硕士生导师,苏州市青年科技托举人才。2013年和2018年获苏州大学放射医学专业学士学位和博士学位(导师:高明远教授、史海斌教授),2018年于苏州大学生物医学研究院从事免疫学相关博士后研究,2023年受聘为苏州大学副教授。研究方向:新型功能生物医用材料及纳米分子探针设计构建,探索其在肿瘤放射免疫治疗监控与调控等前沿领域的应用,推动基础研究向临床转化。主持承担国家青C、江苏省青年、博士后特别资助和面上资助项目等10余项。担任江苏省研究型医院学会感染与炎症放射学专委会委员、《Cancers》杂志客座编辑以及《Bioactive materials》、《Seminars in immunology》杂志审稿人等。获教育部自然科学一等奖、苏州市医学科技一等奖和苏州市自然科学优秀论文二等奖。以第一或通讯作者在J. Am. Chem. Soc.(2篇)、Adv. Mater.(1篇)、ACS Nano(3篇)、EBMO J.(1篇)、Trends Immunol.(1篇)等国际重要学术期刊上发表SCI论文20余篇,总引用1900余次,单篇最高引405次,授权发明专利6项。指导本科生获国家级大创项目(2025)、江苏省大创项目(优秀结题)以及苏州大学莙政项目(2025)等课外科研项目多项。
科研项目:
1.苏州市基础研究项目子课题(合作研究项目),耗竭型T细胞可视化调控以增效肿瘤放疗及其机制研究,2025.04-2026.10,10万元,在研,主持
2.江苏省高等学校自然科学研究面上项目,24KJB310016,靶向调控肿瘤浸润T细胞耗竭及其疗效可视化评价研究,2024.07-2026.07,3万,主持,在研
3.苏州医学院医学交叉种子基金,髓源性抑制细胞铁死亡及其改善放疗抵抗机制研究,YXY2304036,20万,2023.10-2025.09,主持,结题
4.国家自然科学基金青年项目,81902913,PD1免疫检查点小分子抑制剂PSdis的抗肿瘤研究,20.5万,2020-01至2022-12,主持,结题
5.江苏省自然科学基金青年项目,BK20190821,基于PD1免疫节点小分子纳米药物的肿瘤免疫治疗研究,20万,2019-07至2022-06,主持,结题
代表性论著:
1.Miao Li, Jinfeng Zhu, Zhengzhong Lv, Zhixin Han, Yuqi Zhang, Xingxiang Ren, Yurong Fan, Hongyuan Wen, Yiming Feng, Yan Chen, Yongxiang Bai, Danyang Ji,*Xiaju Cheng,* Haibin Shi*,Light-mediated In-situ Synchronous Capture of Antigens and Nucleic Acids as Nanovaccines to Boost Tumor Radioimmunotherapy,Journal of the American Chemical Society,2026, Accept.
2.Zhengzhong Lv, Miao Li, Jinfeng Zhu, Yirui Guo, Yuqi Zhang, Zhongsheng Zhao, Xingxiang Ren, Yan Chen, Zhixin Han, Yiming Feng,Xiaju Cheng,* and Haibin Shi*, Engineering TLR7/8 Agonist-Loaded and Tumor-anchored Gold Nanosensitizers for Enhanced Radioimmunotherapy,Small,2025, 21, e2503133.
3.Xue Li#,*, Xiangrong Li#, Pengpeng Huang, Facai Zhang, Juanjuan K Du, Ying Kong, Ziqiang Shao, Xinxing Wu, Weijiao Fan, Houquan Tao, Chuanzan Zhou,Yan Shao, Yanling Jin, Meihua Ye, Yan Chen, Jong Deng, Jimin Shao, Jicheng Yue,Xiaju Cheng*, Y. Eugene Chinn*, Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis.EMBO Journal, 2024, 43, 4954-4983.
4.Jinfeng Zhu#, Miao Li#, Yuqi Zhang, Zhengzhong Lv, Zhongsheng Zhao, Yirui Guo, Yan Chen, Xingxiang Ren,Xiaju Cheng*, Haibin Shi*, S-Sulfenylation Driven Antigen Capture Boosted by Radiation for Enhanced Cancer Immunotherapy.ACS Nano,2024, 18, 20142-20156.
5.Wen Zhu#,Xiaju Cheng#, Pei Xu#, Yuan Gu, Hanye Xu, Jingwei Xu, Yangyun Wang, Leshuai W. Zhang, Yong Wang*, Radiotherapy-Driven Nanoprobes Targeting for Visualizing Tumor Infiltration Dynamics and Inducing Ferroptosis in Myeloid-Derived Suppressor Cells.Journal of the American Chemical Society,2024, 146, 22455-22468.
6.Jiachen Li,Zhengzhong Lv,Yirui Guo,Jing Fang,Anna Wang,Yali Feng,Yuqi Zhang,Jinfeng Zhu,Zhongsheng Zhao,Xiaju Cheng*,Haibin Shi*, Hafnium (Hf)-Chelating Porphyrin-Decorated Gold Nanosensitizers for Enhanced Radio-Radiodynamic Therapy of Colon Carcinoma.ACS Nano,2023, 17, 25147-25156.
7.XiajuCheng#,JiahaoShen#,JingweiXu,JinfengZhu,PeiXu,YongWang,MingyuanGao,In vivo clinical molecular imaging of T cell activity.Trends in Immunology,2023, 44, 1031-1045.
8.Mohammad Javad Afshari#,Xiaju Cheng#, Guangxin Duan, Ruixue Duan, Shuwang Wu, Jianfeng Zeng*, Zi Gu*, Mingyuan Gao*,Vision for Ratiometric Nanoprobes: In Vivo Noninvasive Visualization and Readout of Physiological Hallmarks,ACS Nano,2023, 17, 7109-7134.
9.Rui Sun#, Yuqi Zhang#, Yinjia Gao, Meng Zhao, Anna Wang, Jinfeng Zhu,Xiaju Cheng*, Haibin Shi*, A tumor-targetable NIR probe with photoaffinity crosslinking characteristics for enhanced imaging-guided cancer phototherapy,Chemical Science,2023, 14, 2369-2378.
10.XiajuCheng#,XiuxiaZhou#,JingweiXu#,RuiSun,HuaweiXia,JiananDing,Y eugeneChin,ZhifangChai ZF,HaibinShi*,MingyuanGao*. Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors.Analytical Chemistry,2021, 93,9277-9285.
11.Xiaju Cheng, Rui Sun, Ling Yin, Zhifang Chai, Haibin Shi*, Mingyuan Gao*.Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and PhotoacousticImaging of Tumours In Vivo.Advanced Materials,2017, 6, 1604894.
获奖
1.高明远,李桢,汪勇,史海斌,曾剑锋,文玲,高振宇,张少华,程侠菊,2020年高等学校优秀教育成果奖(科学技术)一等奖,排9
2.程侠菊,孙瑞,2016-2017年度苏州市自然科学优秀论文二等奖,排1
3.史海斌,陈卫昌,汪勇,曾剑锋,朱然,栾富娟,程侠菊,何蕾,2019年苏州市医学会医学科技奖一等奖,排7
授权专利:
1.史海斌,高明远,程侠菊,孙瑞。紫外光介导的纳米颗粒自组装聚集体、其制备方法和应用,专利号:201610723117.1(已授权)
2.史海斌,高明远,程侠菊,孙瑞。叶酸修饰的金纳米颗粒及其制备方法与在制备放射增敏治疗药物中的应用,专利号:201810172584.9(已授权)
3.史海斌,高明远,程侠菊,孙瑞。紫外光介导的纳米颗粒自组装聚集体和应用,专利号:201910351907.5(已授权)
4.秦樾,程侠菊,裴剑锋,陈福贤。一种靶向免疫节点PD-1与SHP-2互作的先导化合物及其应用,专利号:202010298729.7(已授权)
5.程侠菊,李乾,吴书旺,吴永友,华润佳,许经伟,一种瘤内原位交联水凝胶纳米复合物及其制备方法和应用,专利号:202411907910.8(已授权)
6.吴书旺,程侠菊,蒋昱娇,华润佳,刘春毅,耿金刚,一种三维细胞球培养装置及其培养方法,专利号:202410366166.9(已授权)
课程教学及招生信息
1.放射医学、免疫学、生物材料(研究生、本科生课程)